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• W2000414710 abstract "Magnetization transfer imaging is sensitive to the proportion of free and bound protons in the brain tissue, and so may reflect the microstructural changes that accompany and may well precede macrostructural atrophy seen on volumetric MR sequences. 18 patients with probable mild to moderate AD (8 females, mean(SD) age: 69.1(6.8) years, MMSE: 19(6)) and 18 matched controls (7 females, 67.1(8.9) yrs, 30(1)) had MR imaging to generate volumetric magnetization-transfer ratio (MTR) maps and volumetric T1-weighted (T1w) images using a 1.5T GE Signa scanner. T1w images were segmented, and spatially normalised using Dartel in SPM8. MTR maps were coregistered to the corresponding T1w images, and then normalised with the same Dartel transformation. To perform voxel-based morphometry (VBM) normalised gray matter (GM) and white matter (WM) segments were smoothed with a 6mm full-width at half-maximum Gaussian kernel. MTR maps were smoothed by the same amount, but using a tissue-compensated approach [1] that avoids blurring MTR across tissue-types (MTR is very low in CSF, and not of interest in scalp or skull). The sum of unnormalised GM, WM and CSF segments was used to estimate total intracranial volume (TIV). Statistical analysis of each separate set of images was performed in SPM8, using ANCOVA to compare groups controlling for age, gender, and TIV. Multiple comparisons were corrected to control false discovery rate at 5%. [1] Lee et al. (2009) NeuroImage 44(3):870-883. Figure-1 shows areas of significant difference between patients and controls in GM volume and MTR, and WM volume and MTR. While GM volume loss was most significant in the medial temporal lobe structures, there was widespread increase in MTR throughout the GM. WM volume and MTR changes were less widespread, but most evident on MTR in the parietal WM. The results suggest that in mild-to-moderate AD diffuse microstructural changes, as evidenced by MTR, are widespread through grey matter, including areas where macrostructural neocortical atrophy is not obviously present. This implies that MTR provides complementary information and may add discriminatory value to volumetric imaging. MTR may be useful in assessing disease progression or response to disease modifying therapy." @default.
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• W2000414710 date "2010-07-01" @default.
• W2000414710 modified "2023-09-27" @default.
• W2000414710 title "P4-059: Statistical Parametric Mapping Analysis of Magnetization Transfer Ratio in Alzheimer's Disease: Comparison With Volumetric Imaging" @default.
• W2000414710 doi "https://doi.org/10.1016/j.jalz.2010.08.119" @default.
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