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- W2000415049 abstract "Previous studies in our laboratories showed that a novel nonionic liposome formulation composed of glyceryl dilaurate (GDL), cholesterol (CH), and polyoxyethylene-10-stearyl ether (POE-10) at a weight ratio composition of 57:15:28 delivered more cyclosporin-A (CsA) into and through the skin than phospholipid-based liposomal formulations and more conventional formulations that were tested. Since only a single GDL:CH:POE-10 composition was tested, we initiated studies to determine if it would be possible to control the rate and extent of drug uptake by varying the ratios of the liposome-forming components of the formulation. This report describes how the GDL to POE-10 ratio (CH being held constant at 15 wt%) influences the rate and extent of uptake of CsA following topical application of nonionic liposomal formulations to hairless mouse skin mounted on Franz diffusion cells. The results indicate that the rate and extent of CsA uptake is highest between GDL/POE-10 ratios of about 1 to 1.5 and decreases steadily at ratios above and below this range. The effect of liposomal composition on CsA deposition is probably the result of a number of complex and interrelated factors including partitioning of CsA from the formulation into the skin and permeation enhancer effects." @default.
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- W2000415049 date "1997-01-01" @default.
- W2000415049 modified "2023-09-23" @default.
- W2000415049 title "Effect of Lipid Composition on Topical Delivery of Cyclosporin-A from Nonionic Ldtosomal Formulations: An in Vitro Study with Hairless Mouse Skin" @default.
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- W2000415049 doi "https://doi.org/10.3109/08982109709035501" @default.
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