Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000415207> ?p ?o ?g. }
- W2000415207 endingPage "135" @default.
- W2000415207 startingPage "126" @default.
- W2000415207 abstract "Neocortical and striatal TRPV1 (vanilloid or capsaicin) receptors (TRPV1Rs) are excitatory ligand-gated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV1Rs in glutamatergic, serotonergic or dopaminergic terminals of the rodent forebrain remains little understood. With the help of patch-clamp electrophysiology and neurochemical approaches, we mapped the age-dependence of presynaptic TRPV1R function, and furthermore, we aimed at exploring whether the presence of CB1 cannabinoid receptors (CB1Rs) influences the function of the TRPV1Rs, as both receptor types share endogenous ligands. We found that the major factor which affects presynaptic TRPV1R function is age: by post-natal day 13, the amplitude of capsaicin-induced release of dopamine and glutamate is halved in the rat striatum, and two weeks later, capsaicin already loses its effect. However, TRPV1R receptor function is not enhanced by chemical or genetic ablation of the CB1Rs in dopaminergic, glutamatergic and serotonergic terminals of the mouse brain. Altogether, our data indicate a possible neurodevelopmental role for presynaptic TRPV1Rs in the rodent brain, but we found no cross-talk between TRPV1Rs and CB1Rs in the same nerve terminal." @default.
- W2000415207 created "2016-06-24" @default.
- W2000415207 creator A5004177548 @default.
- W2000415207 creator A5008153051 @default.
- W2000415207 creator A5022431389 @default.
- W2000415207 creator A5025153271 @default.
- W2000415207 creator A5028854446 @default.
- W2000415207 creator A5062951740 @default.
- W2000415207 creator A5079611560 @default.
- W2000415207 creator A5086854665 @default.
- W2000415207 date "2013-08-01" @default.
- W2000415207 modified "2023-10-16" @default.
- W2000415207 title "Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain" @default.
- W2000415207 cites W102833560 @default.
- W2000415207 cites W1488291522 @default.
- W2000415207 cites W1490982132 @default.
- W2000415207 cites W1506056832 @default.
- W2000415207 cites W1511198581 @default.
- W2000415207 cites W1567125032 @default.
- W2000415207 cites W1569255175 @default.
- W2000415207 cites W1577825478 @default.
- W2000415207 cites W1592286181 @default.
- W2000415207 cites W1593555249 @default.
- W2000415207 cites W1593680573 @default.
- W2000415207 cites W1916800927 @default.
- W2000415207 cites W1964172282 @default.
- W2000415207 cites W1964358846 @default.
- W2000415207 cites W1965280907 @default.
- W2000415207 cites W1967910172 @default.
- W2000415207 cites W1970855023 @default.
- W2000415207 cites W1973150838 @default.
- W2000415207 cites W1982699413 @default.
- W2000415207 cites W1986101163 @default.
- W2000415207 cites W1987589683 @default.
- W2000415207 cites W1989915314 @default.
- W2000415207 cites W1992150198 @default.
- W2000415207 cites W1996892917 @default.
- W2000415207 cites W1997037638 @default.
- W2000415207 cites W2005312899 @default.
- W2000415207 cites W2006446151 @default.
- W2000415207 cites W2009587269 @default.
- W2000415207 cites W2010086382 @default.
- W2000415207 cites W2015830587 @default.
- W2000415207 cites W2015923748 @default.
- W2000415207 cites W2019659882 @default.
- W2000415207 cites W2022071529 @default.
- W2000415207 cites W2022737700 @default.
- W2000415207 cites W2025993638 @default.
- W2000415207 cites W2030593013 @default.
- W2000415207 cites W2033743296 @default.
- W2000415207 cites W2035943162 @default.
- W2000415207 cites W2038631083 @default.
- W2000415207 cites W2039432579 @default.
- W2000415207 cites W2039626819 @default.
- W2000415207 cites W2042587343 @default.
- W2000415207 cites W2043866703 @default.
- W2000415207 cites W2044632947 @default.
- W2000415207 cites W2050519455 @default.
- W2000415207 cites W2052148515 @default.
- W2000415207 cites W2053251168 @default.
- W2000415207 cites W2056230353 @default.
- W2000415207 cites W2060016785 @default.
- W2000415207 cites W2060277249 @default.
- W2000415207 cites W2073533991 @default.
- W2000415207 cites W2074437114 @default.
- W2000415207 cites W2077440026 @default.
- W2000415207 cites W2078681187 @default.
- W2000415207 cites W2084766767 @default.
- W2000415207 cites W2085802434 @default.
- W2000415207 cites W2089362566 @default.
- W2000415207 cites W2090285005 @default.
- W2000415207 cites W2091045968 @default.
- W2000415207 cites W2106537627 @default.
- W2000415207 cites W2114251305 @default.
- W2000415207 cites W2117887655 @default.
- W2000415207 cites W2145724426 @default.
- W2000415207 cites W2168499817 @default.
- W2000415207 cites W2171260594 @default.
- W2000415207 cites W2171584675 @default.
- W2000415207 cites W69341822 @default.
- W2000415207 doi "https://doi.org/10.1016/j.brainresbull.2013.06.007" @default.
- W2000415207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23831917" @default.
- W2000415207 hasPublicationYear "2013" @default.
- W2000415207 type Work @default.
- W2000415207 sameAs 2000415207 @default.
- W2000415207 citedByCount "13" @default.
- W2000415207 countsByYear W20004152072014 @default.
- W2000415207 countsByYear W20004152072016 @default.
- W2000415207 countsByYear W20004152072017 @default.
- W2000415207 countsByYear W20004152072019 @default.
- W2000415207 countsByYear W20004152072020 @default.
- W2000415207 crossrefType "journal-article" @default.
- W2000415207 hasAuthorship W2000415207A5004177548 @default.
- W2000415207 hasAuthorship W2000415207A5008153051 @default.
- W2000415207 hasAuthorship W2000415207A5022431389 @default.
- W2000415207 hasAuthorship W2000415207A5025153271 @default.
- W2000415207 hasAuthorship W2000415207A5028854446 @default.
- W2000415207 hasAuthorship W2000415207A5062951740 @default.