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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000416991> ?p ?o ?g. }

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• W2000416991 abstract "A series of biphenylaminocyclopropane carboxamide based bradykinin B1 receptor antagonists has been developed that possesses good pharmacokinetic properties and is CNS penetrant. Discovery that the replacement of the trifluoropropionamide in the lead structure with polyhaloacetamides, particularly a trifluoroacetamide, significantly reduced P-glycoprotein mediated efflux for the series proved essential. One of these novel bradykinin B1 antagonists (13b) also exhibited suitable pharmacokinetic properties and efficient ex vivo receptor occupancy for further development as a novel approach for the treatment of pain and inflammation." @default.
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• W2000416991 date "2006-12-23" @default.
• W2000416991 modified "2023-10-13" @default.
• W2000416991 title "Development of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B₁ Receptor Antagonists" @default.
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• W2000416991 doi "https://doi.org/10.1021/jm061094b" @default.
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