Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000417464> ?p ?o ?g. }
- W2000417464 endingPage "1267" @default.
- W2000417464 startingPage "1257" @default.
- W2000417464 abstract "Pulsed ultrasound, when used as an adjuvant to recombinant tissue plasminogen activator (rt-PA), has been shown to enhance thrombolysis in the laboratory as well as in clinical trials for the treatment of ischemic stroke. The exact mechanism of this enhancement has not yet been elucidated. In this work, stable and inertial cavitation (SC and IC) are investigated as possible mechanisms for this enhancement. A passive cavitation detection scheme was utilized to measure cavitation thresholds at 120 kHz (80% duty cycle, 1667 Hz pulse repetition frequency) for four host fluid and sample combinations: plasma, plasma with rt-PA, plasma with clot and plasma with clot and rt-PA. Following cavitation threshold determination, clots were exposed to pulsed ultrasound for 30 min in vitro using three separate ultrasound treatment regimes: (1) no cavitation (0.15 MPa), (2) SC alone (0.24 MPa) or (3) SC + IC combined (0.36 MPa) in the presence of rt-PA. Percent clot mass loss after each treatment was used to determine thrombolysis efficacy. The highest percent mass loss was observed in the stable cavitation regime (26%), followed by the combined stable and inertial cavitation regime (20.7%). Interestingly, the percent mass loss in clots exposed to ultrasound without cavitation (13.7%) was not statistically significantly different from rt-PA alone (13%) [p > 0.05]. Significant enhancement of thrombolysis correlates with presence of cavitation and stable cavitation appears to play a more important role in the enhancement of thrombolysis. (E-mail: )." @default.
- W2000417464 created "2016-06-24" @default.
- W2000417464 creator A5006760900 @default.
- W2000417464 creator A5009840006 @default.
- W2000417464 creator A5031465172 @default.
- W2000417464 creator A5042082739 @default.
- W2000417464 creator A5042731335 @default.
- W2000417464 creator A5072450920 @default.
- W2000417464 creator A5076460533 @default.
- W2000417464 date "2006-08-01" @default.
- W2000417464 modified "2023-09-30" @default.
- W2000417464 title "Correlation of cavitation with ultrasound enhancement of thrombolysis" @default.
- W2000417464 cites W1472997 @default.
- W2000417464 cites W1963973205 @default.
- W2000417464 cites W1965486958 @default.
- W2000417464 cites W1971037061 @default.
- W2000417464 cites W1977391825 @default.
- W2000417464 cites W1979184736 @default.
- W2000417464 cites W1984602682 @default.
- W2000417464 cites W1986435507 @default.
- W2000417464 cites W1992102502 @default.
- W2000417464 cites W1996802760 @default.
- W2000417464 cites W2002927050 @default.
- W2000417464 cites W2005751180 @default.
- W2000417464 cites W2011766727 @default.
- W2000417464 cites W2019571828 @default.
- W2000417464 cites W2024892486 @default.
- W2000417464 cites W2026253269 @default.
- W2000417464 cites W2026861398 @default.
- W2000417464 cites W2031382292 @default.
- W2000417464 cites W2031846139 @default.
- W2000417464 cites W2036099445 @default.
- W2000417464 cites W2038044402 @default.
- W2000417464 cites W2038567571 @default.
- W2000417464 cites W2049326508 @default.
- W2000417464 cites W205495280 @default.
- W2000417464 cites W2059684874 @default.
- W2000417464 cites W2066687163 @default.
- W2000417464 cites W2071959280 @default.
- W2000417464 cites W2082984233 @default.
- W2000417464 cites W2083582183 @default.
- W2000417464 cites W2088546638 @default.
- W2000417464 cites W2088569279 @default.
- W2000417464 cites W2089310825 @default.
- W2000417464 cites W2091655060 @default.
- W2000417464 cites W2105665820 @default.
- W2000417464 cites W2107906913 @default.
- W2000417464 cites W2120685640 @default.
- W2000417464 cites W2135497424 @default.
- W2000417464 cites W2139377009 @default.
- W2000417464 cites W2155358498 @default.
- W2000417464 cites W2157523095 @default.
- W2000417464 cites W2165973793 @default.
- W2000417464 cites W2170684834 @default.
- W2000417464 cites W2292308933 @default.
- W2000417464 cites W2330752745 @default.
- W2000417464 cites W2407998854 @default.
- W2000417464 cites W4236762092 @default.
- W2000417464 cites W4240263638 @default.
- W2000417464 cites W4252601438 @default.
- W2000417464 cites W94162627 @default.
- W2000417464 doi "https://doi.org/10.1016/j.ultrasmedbio.2006.04.008" @default.
- W2000417464 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1937506" @default.
- W2000417464 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16875959" @default.
- W2000417464 hasPublicationYear "2006" @default.
- W2000417464 type Work @default.
- W2000417464 sameAs 2000417464 @default.
- W2000417464 citedByCount "252" @default.
- W2000417464 countsByYear W20004174642012 @default.
- W2000417464 countsByYear W20004174642013 @default.
- W2000417464 countsByYear W20004174642014 @default.
- W2000417464 countsByYear W20004174642015 @default.
- W2000417464 countsByYear W20004174642016 @default.
- W2000417464 countsByYear W20004174642017 @default.
- W2000417464 countsByYear W20004174642018 @default.
- W2000417464 countsByYear W20004174642019 @default.
- W2000417464 countsByYear W20004174642020 @default.
- W2000417464 countsByYear W20004174642021 @default.
- W2000417464 countsByYear W20004174642022 @default.
- W2000417464 countsByYear W20004174642023 @default.
- W2000417464 crossrefType "journal-article" @default.
- W2000417464 hasAuthorship W2000417464A5006760900 @default.
- W2000417464 hasAuthorship W2000417464A5009840006 @default.
- W2000417464 hasAuthorship W2000417464A5031465172 @default.
- W2000417464 hasAuthorship W2000417464A5042082739 @default.
- W2000417464 hasAuthorship W2000417464A5042731335 @default.
- W2000417464 hasAuthorship W2000417464A5072450920 @default.
- W2000417464 hasAuthorship W2000417464A5076460533 @default.
- W2000417464 hasBestOaLocation W20004174642 @default.
- W2000417464 hasConcept C121332964 @default.
- W2000417464 hasConcept C126838900 @default.
- W2000417464 hasConcept C136229726 @default.
- W2000417464 hasConcept C143753070 @default.
- W2000417464 hasConcept C164705383 @default.
- W2000417464 hasConcept C192562407 @default.
- W2000417464 hasConcept C207057113 @default.
- W2000417464 hasConcept C24890656 @default.
- W2000417464 hasConcept C2779581417 @default.