Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000418535> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2000418535 endingPage "44" @default.
- W2000418535 startingPage "41" @default.
- W2000418535 abstract "5-(1-Azidovinyl)-2'-deoxyuridine (AzVDU) and a series of 5-[1-azido-2-halogenoethyl]-derivatives of beta-D-arabinofuranosyluracil (AU) proved markedly inhibitory to the replication of herpes simplex virus type 1 (HSV-1) and varicella zoster virus (VZV), but not thymidine kinase (TK)-deficient HSV-1 and VZV strains. None of the compounds were cytostatic. However, AzVDU, but not the 5-[1-azido-2-halogenoethyl]-AU derivatives became highly cytostatic against HSV-1 and HSV-2 TK gene-transfected FM3A tumor cells. The molecular target for the cytostatic effect of AzVDU proved to be thymidylate synthase. Short exposure of AzVDU-treated FM3A TK-/HSV-1 TK+ cells to irradiation at lambda = 254 nm enhanced the cytostatic activity of AzVDU by 5-fold." @default.
- W2000418535 created "2016-06-24" @default.
- W2000418535 creator A5029131734 @default.
- W2000418535 creator A5030479730 @default.
- W2000418535 creator A5040662398 @default.
- W2000418535 creator A5068886356 @default.
- W2000418535 creator A5085859262 @default.
- W2000418535 creator A5090932339 @default.
- W2000418535 date "1995-10-02" @default.
- W2000418535 modified "2023-09-27" @default.
- W2000418535 title "The cytostatic activity of 5-(1-azidovinyl)-2′-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (λ= 254 nm) exposure" @default.
- W2000418535 cites W1566196238 @default.
- W2000418535 cites W1988089055 @default.
- W2000418535 cites W1989612042 @default.
- W2000418535 cites W2016138321 @default.
- W2000418535 cites W2049457501 @default.
- W2000418535 cites W2063353401 @default.
- W2000418535 cites W2064128298 @default.
- W2000418535 cites W2089286733 @default.
- W2000418535 doi "https://doi.org/10.1016/0014-5793(95)00994-k" @default.
- W2000418535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7589430" @default.
- W2000418535 hasPublicationYear "1995" @default.
- W2000418535 type Work @default.
- W2000418535 sameAs 2000418535 @default.
- W2000418535 citedByCount "12" @default.
- W2000418535 countsByYear W20004185352018 @default.
- W2000418535 countsByYear W20004185352022 @default.
- W2000418535 crossrefType "journal-article" @default.
- W2000418535 hasAuthorship W2000418535A5029131734 @default.
- W2000418535 hasAuthorship W2000418535A5030479730 @default.
- W2000418535 hasAuthorship W2000418535A5040662398 @default.
- W2000418535 hasAuthorship W2000418535A5068886356 @default.
- W2000418535 hasAuthorship W2000418535A5085859262 @default.
- W2000418535 hasAuthorship W2000418535A5090932339 @default.
- W2000418535 hasConcept C104317684 @default.
- W2000418535 hasConcept C121608353 @default.
- W2000418535 hasConcept C123321153 @default.
- W2000418535 hasConcept C153911025 @default.
- W2000418535 hasConcept C159047783 @default.
- W2000418535 hasConcept C181199279 @default.
- W2000418535 hasConcept C185592680 @default.
- W2000418535 hasConcept C202751555 @default.
- W2000418535 hasConcept C2522874641 @default.
- W2000418535 hasConcept C2776147627 @default.
- W2000418535 hasConcept C2776735402 @default.
- W2000418535 hasConcept C2777108182 @default.
- W2000418535 hasConcept C2777111502 @default.
- W2000418535 hasConcept C2780456651 @default.
- W2000418535 hasConcept C2781196997 @default.
- W2000418535 hasConcept C54009773 @default.
- W2000418535 hasConcept C54355233 @default.
- W2000418535 hasConcept C552990157 @default.
- W2000418535 hasConcept C55493867 @default.
- W2000418535 hasConcept C86803240 @default.
- W2000418535 hasConcept C89138240 @default.
- W2000418535 hasConceptScore W2000418535C104317684 @default.
- W2000418535 hasConceptScore W2000418535C121608353 @default.
- W2000418535 hasConceptScore W2000418535C123321153 @default.
- W2000418535 hasConceptScore W2000418535C153911025 @default.
- W2000418535 hasConceptScore W2000418535C159047783 @default.
- W2000418535 hasConceptScore W2000418535C181199279 @default.
- W2000418535 hasConceptScore W2000418535C185592680 @default.
- W2000418535 hasConceptScore W2000418535C202751555 @default.
- W2000418535 hasConceptScore W2000418535C2522874641 @default.
- W2000418535 hasConceptScore W2000418535C2776147627 @default.
- W2000418535 hasConceptScore W2000418535C2776735402 @default.
- W2000418535 hasConceptScore W2000418535C2777108182 @default.
- W2000418535 hasConceptScore W2000418535C2777111502 @default.
- W2000418535 hasConceptScore W2000418535C2780456651 @default.
- W2000418535 hasConceptScore W2000418535C2781196997 @default.
- W2000418535 hasConceptScore W2000418535C54009773 @default.
- W2000418535 hasConceptScore W2000418535C54355233 @default.
- W2000418535 hasConceptScore W2000418535C552990157 @default.
- W2000418535 hasConceptScore W2000418535C55493867 @default.
- W2000418535 hasConceptScore W2000418535C86803240 @default.
- W2000418535 hasConceptScore W2000418535C89138240 @default.
- W2000418535 hasIssue "1" @default.
- W2000418535 hasLocation W20004185351 @default.
- W2000418535 hasLocation W20004185352 @default.
- W2000418535 hasOpenAccess W2000418535 @default.
- W2000418535 hasPrimaryLocation W20004185351 @default.
- W2000418535 hasRelatedWork W1970295803 @default.
- W2000418535 hasRelatedWork W2000418535 @default.
- W2000418535 hasRelatedWork W2016686224 @default.
- W2000418535 hasRelatedWork W2026282868 @default.
- W2000418535 hasRelatedWork W2082608583 @default.
- W2000418535 hasRelatedWork W2189318661 @default.
- W2000418535 hasRelatedWork W2342812949 @default.
- W2000418535 hasRelatedWork W2418859293 @default.
- W2000418535 hasRelatedWork W2418992611 @default.
- W2000418535 hasRelatedWork W2427332626 @default.
- W2000418535 hasVolume "373" @default.
- W2000418535 isParatext "false" @default.
- W2000418535 isRetracted "false" @default.
- W2000418535 magId "2000418535" @default.
- W2000418535 workType "article" @default.