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- W2000418766 abstract "Abstract Chlormadinone acetate (CAP) was given orally for 42 days to four groups of 15 regularly cycling Hereford heifers in Central Mexico (19°N, altitude 2200 m). The CAP doses (0.625; 1.25 and 2.5 mg/day per animal) represent 1/16th, 1/8th and 1/4th, respectively, of the cycle synchronizing dose of 10 mg. Heat was observed for 1 hour at 06.00, 12.00 and 18.00 h and animals in heat were rectally palpated at 6 h intervals until ovulation had occurred. Observations continued for the duration of the treatment period and 26 days thereafter. CAP treatment had significant effects. With 2.5 mg, occurrence of the next heat was delayed in 8 and inhibited in 6 animals; nine animals had synchronized heat after CAP withdrawal; five animals did not ovulate but developed luteinized follicles; animals not cycling had prolonged periods of vulvar swelling. With 1.25 mg CAP, most animals continued cycling, but estrous intervals were prolonged and 3 animals developed luteinized follicles. With 0.625 mg CAP, only a slight prolongation in estrous intervals and of the heat periods was observed. Individual differences in response to CAP were marked in all treatment groups. CAP at the higher doses interfered with mechanisms of ovulation and was partially effective in preventing heat and follicular development. In cycling animals the length of the cycle, the duration of heat and the daily variations of the onset of heat were within reported limits. The interval between disappearance of heat symptoms and ovulations (21.23 h) was about twice that reported in the literature. Ovulations followed a daily rhythm with a major peak between 24.00 and 0.600 h and a minor elevation between 12.00 and 18.00 h." @default.
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- W2000418766 date "1978-02-01" @default.
- W2000418766 modified "2023-09-26" @default.
- W2000418766 title "The effect of long-term administration of low oral doses of chlormadinone acetate on heat cycles and ovarian functions in beef heifers" @default.
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- W2000418766 doi "https://doi.org/10.1016/0093-691x(78)90143-7" @default.
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