FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000419837> ?p ?o ?g. }

• W2000419837 endingPage "135" @default.
• W2000419837 startingPage "126" @default.
• W2000419837 abstract "Genetically engineered mouse models (GEMMs) of lung cancer closely recapitulate the human disease but suffer from the difficulty of evaluating tumor growth by conventional methods. Herein, a novel automated image analysis method for estimating the lung tumor burden from in vivo micro-computed tomography (micro-CT) data is described. The proposed tumor burden metric is the segmented soft tissue volume contained within a chest space region of interest, excluding an estimate of the heart volume. The method was validated by comparison with previously published manual analysis methods and applied in two therapeutic studies in a mutant K-ras GEMM of non–small cell lung carcinoma. Mice were imaged by micro-CT pre-treatment and stratified into four treatment groups: an antibody inhibiting vascular endothelial growth factor (anti-VEGF), chemotherapy, combination of anti-VEGF and chemotherapy, or control antibody. In the first study, post-treatment imaging was performed 4 weeks later. In the second study, mice were scanned serially on a high-throughput scanner every 2 weeks for 8 weeks during treatment. In both studies, the automated tumor burden estimates were well correlated with manual metrics (r value range: 0.83-0.93, P < .0001) and showed a similar, significant reduction in tumor growth in mice treated with anti-VEGF alone or in combination with chemotherapy. Given the fully automated nature of this technique, the proposed analysis method can provide a valuable tool in preclinical drug research for screening and randomizing animals into treatment groups and evaluating treatment efficacy in mouse models of lung cancer in a highly robust and efficient manner." @default.
• W2000419837 created "2016-06-24" @default.
• W2000419837 creator A5005115402 @default.
• W2000419837 creator A5011497753 @default.
• W2000419837 creator A5011750428 @default.
• W2000419837 creator A5039924656 @default.
• W2000419837 creator A5040110214 @default.
• W2000419837 creator A5043437148 @default.
• W2000419837 creator A5045744095 @default.
• W2000419837 creator A5061317579 @default.
• W2000419837 creator A5062620736 @default.
• W2000419837 creator A5062841169 @default.
• W2000419837 creator A5075396909 @default.
• W2000419837 date "2015-04-01" @default.
• W2000419837 modified "2023-10-18" @default.
• W2000419837 title "Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis" @default.
• W2000419837 cites W130099911 @default.
• W2000419837 cites W1757407923 @default.
• W2000419837 cites W1967213734 @default.
• W2000419837 cites W1967961516 @default.
• W2000419837 cites W1970532505 @default.
• W2000419837 cites W2006406032 @default.
• W2000419837 cites W2007734314 @default.
• W2000419837 cites W2012084975 @default.
• W2000419837 cites W2019607817 @default.
• W2000419837 cites W2028479310 @default.
• W2000419837 cites W203082309 @default.
• W2000419837 cites W2032019019 @default.
• W2000419837 cites W2035252444 @default.
• W2000419837 cites W2038735549 @default.
• W2000419837 cites W2039828110 @default.
• W2000419837 cites W2059958205 @default.
• W2000419837 cites W2101587217 @default.
• W2000419837 cites W2107907914 @default.
• W2000419837 cites W2142377043 @default.
• W2000419837 cites W2147619257 @default.
• W2000419837 cites W2161817637 @default.
• W2000419837 cites W3205413357 @default.
• W2000419837 cites W4238916350 @default.
• W2000419837 doi "https://doi.org/10.1016/j.tranon.2015.03.003" @default.
• W2000419837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4415142" @default.
• W2000419837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25926079" @default.
• W2000419837 hasPublicationYear "2015" @default.
• W2000419837 type Work @default.
• W2000419837 sameAs 2000419837 @default.
• W2000419837 citedByCount "13" @default.
• W2000419837 countsByYear W20004198372015 @default.
• W2000419837 countsByYear W20004198372017 @default.
• W2000419837 countsByYear W20004198372019 @default.
• W2000419837 countsByYear W20004198372021 @default.
• W2000419837 countsByYear W20004198372022 @default.
• W2000419837 countsByYear W20004198372023 @default.
• W2000419837 crossrefType "journal-article" @default.
• W2000419837 hasAuthorship W2000419837A5005115402 @default.
• W2000419837 hasAuthorship W2000419837A5011497753 @default.
• W2000419837 hasAuthorship W2000419837A5011750428 @default.
• W2000419837 hasAuthorship W2000419837A5039924656 @default.
• W2000419837 hasAuthorship W2000419837A5040110214 @default.
• W2000419837 hasAuthorship W2000419837A5043437148 @default.
• W2000419837 hasAuthorship W2000419837A5045744095 @default.
• W2000419837 hasAuthorship W2000419837A5061317579 @default.
• W2000419837 hasAuthorship W2000419837A5062620736 @default.
• W2000419837 hasAuthorship W2000419837A5062841169 @default.
• W2000419837 hasAuthorship W2000419837A5075396909 @default.
• W2000419837 hasBestOaLocation W20004198371 @default.
• W2000419837 hasConcept C121608353 @default.
• W2000419837 hasConcept C126322002 @default.
• W2000419837 hasConcept C126838900 @default.
• W2000419837 hasConcept C142724271 @default.
• W2000419837 hasConcept C143998085 @default.
• W2000419837 hasConcept C150903083 @default.
• W2000419837 hasConcept C207001950 @default.
• W2000419837 hasConcept C2776256026 @default.
• W2000419837 hasConcept C2776694085 @default.
• W2000419837 hasConcept C2777714996 @default.
• W2000419837 hasConcept C2989005 @default.
• W2000419837 hasConcept C71924100 @default.
• W2000419837 hasConcept C86803240 @default.
• W2000419837 hasConceptScore W2000419837C121608353 @default.
• W2000419837 hasConceptScore W2000419837C126322002 @default.
• W2000419837 hasConceptScore W2000419837C126838900 @default.
• W2000419837 hasConceptScore W2000419837C142724271 @default.
• W2000419837 hasConceptScore W2000419837C143998085 @default.
• W2000419837 hasConceptScore W2000419837C150903083 @default.
• W2000419837 hasConceptScore W2000419837C207001950 @default.
• W2000419837 hasConceptScore W2000419837C2776256026 @default.
• W2000419837 hasConceptScore W2000419837C2776694085 @default.
• W2000419837 hasConceptScore W2000419837C2777714996 @default.
• W2000419837 hasConceptScore W2000419837C2989005 @default.
• W2000419837 hasConceptScore W2000419837C71924100 @default.
• W2000419837 hasConceptScore W2000419837C86803240 @default.
• W2000419837 hasIssue "2" @default.
• W2000419837 hasLocation W20004198371 @default.
• W2000419837 hasLocation W20004198372 @default.
• W2000419837 hasLocation W20004198373 @default.
• W2000419837 hasLocation W20004198374 @default.
• W2000419837 hasLocation W20004198375 @default.
• W2000419837 hasOpenAccess W2000419837 @default.

• next