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• W2000421142 abstract "Neuroimaging, particularly that of neuroreceptor radioisotope and functional magnetic resonance imaging (fMRI), has played a fundamental role in neuropharmacology and neurophysiology. Because of the unique and pioneering role, especially of the radiolabeling of central nervous system (CNS) drugs for receptor and neurotransmitter system imaging, there is an increasingly major role to aid in CNS drug development. One component is providing evidence for proof of concept of the target for which candidate drugs are being tested for receptor occupancy mechanism of action and ultimately rational drug dosing. There is also a role for other areas of neuroimaging, including fMRI and magnetic resonance spectroscopy in other magnetic resonance-based techniques that, together with radioisotope imaging, represent ‘CNS molecular imaging.’ The role of these approaches and a review of the recent advances in such neuroimaging for proof-of-concept studies is the subject for this paper. Moreover, hypothetical examples and possible algorithms for early discovery/phase I development using neuroimaging provide specific working approaches. In summary, this article reviews the vital biomarker approach of neuroimaging in proof of concept studies." @default.
• W2000421142 created "2016-06-24" @default.
• W2000421142 creator A5000122559 @default.
• W2000421142 creator A5065952304 @default.
• W2000421142 creator A5081339058 @default.
• W2000421142 date "2008-10-08" @default.
• W2000421142 modified "2023-10-18" @default.
• W2000421142 title "The Role of Imaging in Proof of Concept for CNS Drug Discovery and Development" @default.
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• W2000421142 cites W1676724932 @default.
• W2000421142 cites W1934926274 @default.
• W2000421142 cites W1964637461 @default.
• W2000421142 cites W1968619342 @default.
• W2000421142 cites W1970130998 @default.
• W2000421142 cites W1975271627 @default.
• W2000421142 cites W1981679498 @default.
• W2000421142 cites W1982047175 @default.
• W2000421142 cites W1984320700 @default.
• W2000421142 cites W1988730265 @default.
• W2000421142 cites W1993419754 @default.
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• W2000421142 cites W2011224808 @default.
• W2000421142 cites W2019648896 @default.
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• W2000421142 cites W2031264132 @default.
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• W2000421142 cites W2062509529 @default.
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• W2000421142 cites W2065465755 @default.
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• W2000421142 doi "https://doi.org/10.1038/npp.2008.166" @default.
• W2000421142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18843264" @default.
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