Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000421244> ?p ?o ?g. }
- W2000421244 endingPage "176" @default.
- W2000421244 startingPage "167" @default.
- W2000421244 abstract "Binding of tumor necrosis factor-α (TNF-α) to p60 TNF-α receptor induces the activation of sphingomyelinase to generate ceramide, which in turn activates certain protein kinases and phosphatases, resulting in various TNF-α-mediated biological effects. We have investigated the role for the sphingomyelin/ceramide pathway in the TNF-α-induced upregulation of adhesion molecule expression and tissue factor production of human endothelial cells. TNF-α stimulated human umbilical vascular endothelial cells (HUVECs) to upregulate the expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1) and HLA class I molecules in addition to the induction of procoagulant tissue factor production. C2-ceramide, a highly cell-permeable ceramide analog, was able to stimulate HUVECs to produce tissue factor activity as well as TNF-α. However, C2-ceramide did not stimulate HUVECs to upregulate the expression of VCAM-1, ICAM-1 and HLA class I molecules. These results suggest that there exist both the ceramide-dependent and -independent pathways in TNF-α signal transduction system in human vascular endothelial cells." @default.
- W2000421244 created "2016-06-24" @default.
- W2000421244 creator A5015246317 @default.
- W2000421244 creator A5079113959 @default.
- W2000421244 creator A5086455794 @default.
- W2000421244 creator A5087780421 @default.
- W2000421244 date "2000-01-01" @default.
- W2000421244 modified "2023-10-18" @default.
- W2000421244 title "Induction of Tissue Factor Production but not the Upregulation of Adhesion Molecule Expression by Ceramide in Human Vascular Endothelial Cells" @default.
- W2000421244 cites W113456750 @default.
- W2000421244 cites W1516715449 @default.
- W2000421244 cites W1542941723 @default.
- W2000421244 cites W1555579413 @default.
- W2000421244 cites W1576430359 @default.
- W2000421244 cites W1964788380 @default.
- W2000421244 cites W1969719203 @default.
- W2000421244 cites W1973973055 @default.
- W2000421244 cites W1995391501 @default.
- W2000421244 cites W2017729786 @default.
- W2000421244 cites W2022570497 @default.
- W2000421244 cites W2092330976 @default.
- W2000421244 cites W2101157641 @default.
- W2000421244 cites W2105054347 @default.
- W2000421244 cites W2170928419 @default.
- W2000421244 cites W2409421277 @default.
- W2000421244 cites W2418195982 @default.
- W2000421244 cites W2460292361 @default.
- W2000421244 cites W4294216491 @default.
- W2000421244 doi "https://doi.org/10.1620/tjem.191.167" @default.
- W2000421244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10997557" @default.
- W2000421244 hasPublicationYear "2000" @default.
- W2000421244 type Work @default.
- W2000421244 sameAs 2000421244 @default.
- W2000421244 citedByCount "13" @default.
- W2000421244 countsByYear W20004212442016 @default.
- W2000421244 countsByYear W20004212442022 @default.
- W2000421244 crossrefType "journal-article" @default.
- W2000421244 hasAuthorship W2000421244A5015246317 @default.
- W2000421244 hasAuthorship W2000421244A5079113959 @default.
- W2000421244 hasAuthorship W2000421244A5086455794 @default.
- W2000421244 hasAuthorship W2000421244A5087780421 @default.
- W2000421244 hasBestOaLocation W20004212441 @default.
- W2000421244 hasConcept C104317684 @default.
- W2000421244 hasConcept C126322002 @default.
- W2000421244 hasConcept C127561419 @default.
- W2000421244 hasConcept C16224149 @default.
- W2000421244 hasConcept C17991360 @default.
- W2000421244 hasConcept C185592680 @default.
- W2000421244 hasConcept C185946421 @default.
- W2000421244 hasConcept C186738567 @default.
- W2000421244 hasConcept C190283241 @default.
- W2000421244 hasConcept C203014093 @default.
- W2000421244 hasConcept C2777851122 @default.
- W2000421244 hasConcept C2778382381 @default.
- W2000421244 hasConcept C41625074 @default.
- W2000421244 hasConcept C55493867 @default.
- W2000421244 hasConcept C61322309 @default.
- W2000421244 hasConcept C62478195 @default.
- W2000421244 hasConcept C71924100 @default.
- W2000421244 hasConcept C86803240 @default.
- W2000421244 hasConcept C95444343 @default.
- W2000421244 hasConceptScore W2000421244C104317684 @default.
- W2000421244 hasConceptScore W2000421244C126322002 @default.
- W2000421244 hasConceptScore W2000421244C127561419 @default.
- W2000421244 hasConceptScore W2000421244C16224149 @default.
- W2000421244 hasConceptScore W2000421244C17991360 @default.
- W2000421244 hasConceptScore W2000421244C185592680 @default.
- W2000421244 hasConceptScore W2000421244C185946421 @default.
- W2000421244 hasConceptScore W2000421244C186738567 @default.
- W2000421244 hasConceptScore W2000421244C190283241 @default.
- W2000421244 hasConceptScore W2000421244C203014093 @default.
- W2000421244 hasConceptScore W2000421244C2777851122 @default.
- W2000421244 hasConceptScore W2000421244C2778382381 @default.
- W2000421244 hasConceptScore W2000421244C41625074 @default.
- W2000421244 hasConceptScore W2000421244C55493867 @default.
- W2000421244 hasConceptScore W2000421244C61322309 @default.
- W2000421244 hasConceptScore W2000421244C62478195 @default.
- W2000421244 hasConceptScore W2000421244C71924100 @default.
- W2000421244 hasConceptScore W2000421244C86803240 @default.
- W2000421244 hasConceptScore W2000421244C95444343 @default.
- W2000421244 hasIssue "3" @default.
- W2000421244 hasLocation W20004212441 @default.
- W2000421244 hasLocation W20004212442 @default.
- W2000421244 hasOpenAccess W2000421244 @default.
- W2000421244 hasPrimaryLocation W20004212441 @default.
- W2000421244 hasRelatedWork W1972090215 @default.
- W2000421244 hasRelatedWork W1978813781 @default.
- W2000421244 hasRelatedWork W2000421244 @default.
- W2000421244 hasRelatedWork W2009049966 @default.
- W2000421244 hasRelatedWork W2011057086 @default.
- W2000421244 hasRelatedWork W2093676869 @default.
- W2000421244 hasRelatedWork W2118560029 @default.
- W2000421244 hasRelatedWork W2203977062 @default.
- W2000421244 hasRelatedWork W2894751231 @default.
- W2000421244 hasRelatedWork W328760260 @default.
- W2000421244 hasVolume "191" @default.
- W2000421244 isParatext "false" @default.
- W2000421244 isRetracted "false" @default.