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• W2000421661 abstract "The Bcl-2 protein blocks programmed cell death (apoptosis) through an unknown mechanism. Previously we identified a Bcl-2 interacting protein BAG-1 that enhances the anti-apoptotic effects of Bcl-2. Like BAG-1, the serine/threonine protein kinase Raf-1 also can functionally cooperate with Bcl-2 in suppressing apoptosis. Here we show that Raf-1 and BAG-1 specifically interact in vitro and in yeast two-hybrid assays. Raf-1 and BAG-1 can also be coimmunoprecipitated from mammalian cells and from insect cells infected with recombinant baculoviruses encoding these proteins. Furthermore, bacterially-produced BAG-1 protein can increase the kinase activity of Raf-1 in vitro. BAG-1 also activates this mammalian kinase in yeast. These observations suggest that the Bcl-2 binding protein BAG-1 joins Ras and 14-3-3 proteins as potential activators of the kinase Raf-1." @default.
• W2000421661 created "2016-06-24" @default.
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• W2000421661 date "1996-07-09" @default.
• W2000421661 modified "2023-09-27" @default.
• W2000421661 title "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1." @default.
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• W2000421661 doi "https://doi.org/10.1073/pnas.93.14.7063" @default.
• W2000421661 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38936" @default.
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