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• W2000423251 endingPage "217" @default.
• W2000423251 startingPage "186" @default.
• W2000423251 abstract "Respiratory syncytial virus (RSV) is one of the most important causes of upper and lower respiratory tract infections in infants and young children, for which no effective treatment is currently available. Although the mechanisms of RSV-induced airway disease remain incompletely defined, the lung inflammatory response is thought to play a central pathogenetic role. In the past few years, we and others have provided increasing evidence of a role of reactive oxygen species (ROS) as important regulators of RSV-induced cellular signaling leading to the expression of key proinflammatory mediators, such as cytokines and chemokines. In addition, RSV-induced oxidative stress, which results from an imbalance between ROS production and airway antioxidant defenses, due to a widespread inhibition of antioxidant enzyme expression, is likely to play a fundamental role in the pathogenesis of RSV-associated lung inflammatory disease, as demonstrated by a significant increase in markers of oxidative injury, which correlate with the severity of clinical illness, in children with RSV infection. Modulation of ROS production and oxidative stress therefore represents a potential novel pharmacological approach to ameliorate RSV-induced lung inflammation and its long-term consequences. Antioxid. Redox Signal. 18, 186–217. I. Introduction II. Redox-Sensitive Transcription Factors in RSV Infection A. Nuclear factor-IL6 B. Nuclear factor-kappa B C. Activator protein-1 D. Interferon regulatory factor E. Signal transducers and activators of transcription F. Hypoxia-inducible factor III. ROS in RSV-Induced Cellular Signaling and Oxidative Stress A. ROS generation in RSV infection B. ROS as mediators of cellular signaling in RSV infection 1. NF-κB/NF-IL6/AP-1 activation 2. IRF/STAT activation C. RSV and oxidative stress D. Potential regulatory mechanisms of AOE gene expression in RSV infection IV. Role of Reactive Nitrogen Species in RSV Infection A. NO production and iNOS expression in RSV infection B. Effect of NO on RSV replication, cellular signaling, and lung disease V. Potential Therapeutic Approaches A. Vitamin A B. Vitamin D C. Melatonin D. Thiols E. Polyphenols F. SOD and SOD mimetics G. Nrf2-inducing agents 1. Triterpenoids 2. Sulforaphane and other isothiocyanates 3. Polyphenols 4. Other classes of Nrf2 inducers VI. Conclusions" @default.
• W2000423251 created "2016-06-24" @default.
• W2000423251 creator A5032985331 @default.
• W2000423251 creator A5041514267 @default.
• W2000423251 creator A5063837536 @default.
• W2000423251 date "2013-01-10" @default.
• W2000423251 modified "2023-10-02" @default.
• W2000423251 title "Respiratory Syncytial Virus Infection: Mechanisms of Redox Control and Novel Therapeutic Opportunities" @default.
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