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• W2000423367 abstract "T cells from old mice showed impaired proliferative response to antigenic stimulation. To understand the mechanism underlying the age-related impairment of T cell functions, the signal transduction pathway was examined and compared between T cells from young and old mice, and between T cell clones established from a young and old mouse. The age-related changes in T cells were as follows: (1) reduction in the expression and the activation of protein tyrosine kinases associated with T cell receptor (TCR) after antigenic stimulation; (2) reduced phosphorylation of phospholipase Cγ1 (PLCγ1); (3) reduced production of second messengers such as inositoltrisphosphate (IP3) and diacylglycerol (DAG); and (4) reduced influx of Ca2+ ion. Thus, a T cell clone established from an old mouse showed impaired proliferation by stimulation with anti-CD3 antibody, but was fully activated to the level of a T cell clone from a young mouse by stimulation with phorbol acetate myristate (PMA) plus ionomycin (INM). However, splenic T cells freshly prepared from old mice did not show full recovery by the same treatment. The results indicate that one major blockade in the signal transduction of T cells from old mice is present in the pathway just after TCR , but besides this, the blockade is also present in multiple sites down-stream, which can not be bypassed by stimulation with PMA plus INM." @default.
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• W2000423367 date "1997-02-01" @default.
• W2000423367 modified "2023-10-13" @default.
• W2000423367 title "Impairment of signal transduction in T cells from old mice" @default.
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• W2000423367 doi "https://doi.org/10.1016/s0047-6374(96)01837-4" @default.
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