FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000423770> ?p ?o ?g. }

• W2000423770 abstract "We investigated the inter-relationships of superoxide (O2-) release, membrane depolarization and an increase in cytoplasmic free Ca2+, [Ca2+]i, in human granulocytes stimulated by various agonists. When concanavalin A or the Ca2+ ionophore ionomycin was used as stimulus, an increase in [Ca2+]i clearly preceded the onset of membrane depolarization, which was followed by O2- release. On the other hand, when N-formylmethionylleucylphenylalanine or wheat-germ agglutinin was used as stimulus, no demonstrable lag was seen in any of the responses. O2- release and membrane depolarization stimulated by all these agonists were markedly potentiated in parallel by pretreatment of cells with a low concentration of phorbol myristate acetate (0.25 ng/ml), whereas an increase in [Ca2+]i was not affected or minimally potentiated. The lag time between addition of the stimulus (concanavalin A or ionomycin) and onset of membrane depolarization or O2- release was significantly reduced by pretreatment of cells with phorbol myristate acetate, whereas the lag time between addition of concanavalin A and onset of the increase in [Ca2+]i was not affected. The dose-response curves for triggering of O2- release and membrane depolarization by each of receptor-mediated agonists in phorbol myristate acetate-pretreated or control cells were identical. These findings suggest that; (a) an increase in [Ca2+]i stimulates membrane depolarization indirectly; (b) a low concentration of phorbol myristate acetate potentiates membrane depolarization and O2- release by acting primarily at the post-receptor level, in particular, at the level distal to an increase in [Ca2+]i, but not by augmenting an increase in [Ca2+]i; and (c) the system provoking membrane depolarization and the system activating NADPH oxidase share a common pathway, which may be susceptible to a low concentration of phorbol myristate acetate." @default.
• W2000423770 created "2016-06-24" @default.
• W2000423770 creator A5010974644 @default.
• W2000423770 creator A5013004482 @default.
• W2000423770 creator A5027344168 @default.
• W2000423770 creator A5035619785 @default.
• W2000423770 creator A5035827168 @default.
• W2000423770 creator A5090201638 @default.
• W2000423770 date "1988-06-01" @default.
• W2000423770 modified "2023-10-02" @default.
• W2000423770 title "Phorbol myristate acetate potentiates superoxide release and membrane depolarization without affecting an increase in cytoplasmic free calcium in human granulocytes stimulated by the chemotactic peptide, lectins and the calcium ionophore" @default.
• W2000423770 cites W118981363 @default.
• W2000423770 cites W1218436220 @default.
• W2000423770 cites W1588342196 @default.
• W2000423770 cites W1594758412 @default.
• W2000423770 cites W1601561251 @default.
• W2000423770 cites W1606716377 @default.
• W2000423770 cites W1900423039 @default.
• W2000423770 cites W1964577086 @default.
• W2000423770 cites W1969341626 @default.
• W2000423770 cites W1978887381 @default.
• W2000423770 cites W1992317118 @default.
• W2000423770 cites W2001692359 @default.
• W2000423770 cites W2004860847 @default.
• W2000423770 cites W2023122744 @default.
• W2000423770 cites W2035034278 @default.
• W2000423770 cites W2058871035 @default.
• W2000423770 cites W2061606516 @default.
• W2000423770 cites W2078986317 @default.
• W2000423770 cites W2097984309 @default.
• W2000423770 cites W2112151664 @default.
• W2000423770 cites W2113943014 @default.
• W2000423770 cites W2119672886 @default.
• W2000423770 cites W2219373567 @default.
• W2000423770 cites W2234160446 @default.
• W2000423770 doi "https://doi.org/10.1016/0005-2736(88)90209-x" @default.
• W2000423770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2835980" @default.
• W2000423770 hasPublicationYear "1988" @default.
• W2000423770 type Work @default.
• W2000423770 sameAs 2000423770 @default.
• W2000423770 citedByCount "21" @default.
• W2000423770 countsByYear W20004237702013 @default.
• W2000423770 crossrefType "journal-article" @default.
• W2000423770 hasAuthorship W2000423770A5010974644 @default.
• W2000423770 hasAuthorship W2000423770A5013004482 @default.
• W2000423770 hasAuthorship W2000423770A5027344168 @default.
• W2000423770 hasAuthorship W2000423770A5035619785 @default.
• W2000423770 hasAuthorship W2000423770A5035827168 @default.
• W2000423770 hasAuthorship W2000423770A5090201638 @default.
• W2000423770 hasConcept C11960822 @default.
• W2000423770 hasConcept C12554922 @default.
• W2000423770 hasConcept C126322002 @default.
• W2000423770 hasConcept C134018914 @default.
• W2000423770 hasConcept C178790620 @default.
• W2000423770 hasConcept C181199279 @default.
• W2000423770 hasConcept C185592680 @default.
• W2000423770 hasConcept C195794163 @default.
• W2000423770 hasConcept C19869320 @default.
• W2000423770 hasConcept C202751555 @default.
• W2000423770 hasConcept C2776989580 @default.
• W2000423770 hasConcept C2779014961 @default.
• W2000423770 hasConcept C2780043322 @default.
• W2000423770 hasConcept C2780795997 @default.
• W2000423770 hasConcept C4141045 @default.
• W2000423770 hasConcept C41625074 @default.
• W2000423770 hasConcept C519063684 @default.
• W2000423770 hasConcept C55493867 @default.
• W2000423770 hasConcept C71924100 @default.
• W2000423770 hasConcept C86803240 @default.
• W2000423770 hasConceptScore W2000423770C11960822 @default.
• W2000423770 hasConceptScore W2000423770C12554922 @default.
• W2000423770 hasConceptScore W2000423770C126322002 @default.
• W2000423770 hasConceptScore W2000423770C134018914 @default.
• W2000423770 hasConceptScore W2000423770C178790620 @default.
• W2000423770 hasConceptScore W2000423770C181199279 @default.
• W2000423770 hasConceptScore W2000423770C185592680 @default.
• W2000423770 hasConceptScore W2000423770C195794163 @default.
• W2000423770 hasConceptScore W2000423770C19869320 @default.
• W2000423770 hasConceptScore W2000423770C202751555 @default.
• W2000423770 hasConceptScore W2000423770C2776989580 @default.
• W2000423770 hasConceptScore W2000423770C2779014961 @default.
• W2000423770 hasConceptScore W2000423770C2780043322 @default.
• W2000423770 hasConceptScore W2000423770C2780795997 @default.
• W2000423770 hasConceptScore W2000423770C4141045 @default.
• W2000423770 hasConceptScore W2000423770C41625074 @default.
• W2000423770 hasConceptScore W2000423770C519063684 @default.
• W2000423770 hasConceptScore W2000423770C55493867 @default.
• W2000423770 hasConceptScore W2000423770C71924100 @default.
• W2000423770 hasConceptScore W2000423770C86803240 @default.
• W2000423770 hasLocation W20004237701 @default.
• W2000423770 hasLocation W20004237702 @default.
• W2000423770 hasOpenAccess W2000423770 @default.
• W2000423770 hasPrimaryLocation W20004237701 @default.
• W2000423770 hasRelatedWork W1983775567 @default.
• W2000423770 hasRelatedWork W2000423770 @default.
• W2000423770 hasRelatedWork W2002788320 @default.
• W2000423770 hasRelatedWork W2010001741 @default.
• W2000423770 hasRelatedWork W2023226351 @default.
• W2000423770 hasRelatedWork W2070211997 @default.
• W2000423770 hasRelatedWork W2073516337 @default.

• next