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• W2000424215 abstract "Abstract The success of adoptive cell transfer in the treatment of metastatic cancer in humans is dependent on the selection of highly active tumor-specific cytotoxic T cells. We report here that CTLs capture membrane fragments from their targets while exerting cytotoxic activity and thus gain a detectable functional signature by which they can be identified. Fluorochrome labeling or biotinylation was used to tag tumor cells. CD8+ T cells were coincubated with the tagged targets, sorted, and functionally evaluated. Our results show that membrane capture by CD8+ lymphocytes is T-cell receptor dependent, epitope specific, and preferentially associated with highly cytotoxic clonal subsets. CTLs that captured membranes from unmodified melanoma exhibited enhanced cytotoxic activity against tumor cell lines and autologous melanoma. In a human melanoma in vivo model, adoptive transfer of membrane-capturing, peptide-specific T cells, but not noncapturing or bulk CD8+ T cells, inhibits tumor progression. Membrane capture is therefore a signature of antigen-specific CTLs endowed with high functional avidity and may have direct relevance in the clinical application of adoptive immunotherapy. [Cancer Res 2008;68(6):2006–13]" @default.
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• W2000424215 date "2008-03-13" @default.
• W2000424215 modified "2023-09-23" @default.
• W2000424215 title "Capture of Tumor Cell Membranes by Trogocytosis Facilitates Detection and Isolation of Tumor-Specific Functional CTLs" @default.
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• W2000424215 doi "https://doi.org/10.1158/0008-5472.can-07-3119" @default.
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