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- W2000425445 abstract "Studies of muscle biopsies of 3 infants with dystrophia myotonica revealed changes different from those commonly found in the adult form of the disease and in other congenital hypotonias. By light microscopy there was in most muscle fibres a light peripheral halo particularly clear in preparations stained for oxidative enzymes. A similar halo was demonstrated by electron microscopy which confirmed its poverty in mitochondria: it was formed mainly by sarcoplasm amongst which occurred glycogen granules, some myofilaments and occasional triads. The other changes included diminution in size and increased inequality in the diameter of the muscle fibres, and predominance of Type II fibres. In no case was there a significant relative atrophy of Type I fibres and in 1 case there was smallness of Type II fibres. Degeneration of the various components of the fibres was seen but occasionally. Satellite cells were numerous in all cases. In addition rounded bodies enclosing laminar inclusions of unknown nature were observed in the endothelial cells of some blood capillaries." @default.
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- W2000425445 date "1974-03-01" @default.
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- W2000425445 title "Histochemical and ultrastructural study of muscle biopsies in 3 cases of dystrophia myotonica in the newborn child" @default.
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- W2000425445 doi "https://doi.org/10.1016/0022-510x(74)90172-5" @default.
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