FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000425457> ?p ?o ?g. }

• W2000425457 endingPage "907" @default.
• W2000425457 startingPage "904" @default.
• W2000425457 abstract "The lung cancer caused by jaagsiekte sheep retrovirus (JSRV) — which killed the world's first cloned mammal Dolly — can be duplicated by the expression of just one structural protein of the virus, Env envelope protein. This is the first example of a structural retroviral tumour-causing protein and is rare if not unique among viruses. Surprisingly, immunodeficient mice expressing Env also develop lung cancer whereas immunocompetent mice rarely do. The immune system can block tumorigenesis: sheep are immunotolerant of the virus, which may explain why JSRV seems not to affect most other animals, including humans. It is thought, however, that lung cancer in humans may be due in part to a JSRV-like retrovirus. These new results will focus the search for such viruses on immunocompromised subjects. Jaagsiekte sheep retrovirus (JSRV) causes a contagious lung cancer in sheep and goats, with significant animal health and economic consequences1. The host range of JSRV is in part limited by species-specific differences in the virus entry receptor, hyaluronidase 2 (Hyal2), which is not functional as a receptor in mice but is functional in humans2. Sheep are immunotolerant of JSRV because of the expression of closely related endogenous retroviruses3,4, which are not present in humans and most other species, and this may facilitate oncogenesis. Here we show that expression of the JSRV envelope (Env) protein alone in lungs of mice, by using a replication-incompetent adeno-associated virus vector, results in tumours with a bronchiolo-alveolar localization like those seen in sheep. Whereas lethal disease was observed in immunodeficient mice, tumour development was almost entirely blocked in immunocompetent mice. Our results provide a rare example of an oncogenic viral structural protein, show that interaction of the viral Env protein with the virus entry receptor Hyal2 is not required for tumorigenesis, and indicate that immune recognition of Env can protect against JSRV tumorigenesis." @default.
• W2000425457 created "2016-06-24" @default.
• W2000425457 creator A5026763137 @default.
• W2000425457 creator A5050409687 @default.
• W2000425457 creator A5056457864 @default.
• W2000425457 date "2005-04-01" @default.
• W2000425457 modified "2023-10-17" @default.
• W2000425457 title "Sheep retrovirus structural protein induces lung tumours" @default.
• W2000425457 cites W1943985333 @default.
• W2000425457 cites W1981744882 @default.
• W2000425457 cites W1986645348 @default.
• W2000425457 cites W1989466557 @default.
• W2000425457 cites W1996071244 @default.
• W2000425457 cites W1999334687 @default.
• W2000425457 cites W2000441481 @default.
• W2000425457 cites W2023176816 @default.
• W2000425457 cites W2039386265 @default.
• W2000425457 cites W2042805311 @default.
• W2000425457 cites W2053706844 @default.
• W2000425457 cites W2087431503 @default.
• W2000425457 cites W2095274633 @default.
• W2000425457 cites W2097061428 @default.
• W2000425457 cites W2103535247 @default.
• W2000425457 cites W2107214690 @default.
• W2000425457 cites W2118460485 @default.
• W2000425457 cites W2122979133 @default.
• W2000425457 cites W2129923351 @default.
• W2000425457 cites W2137618410 @default.
• W2000425457 cites W2143662196 @default.
• W2000425457 cites W2144036319 @default.
• W2000425457 cites W2150602071 @default.
• W2000425457 cites W2186563801 @default.
• W2000425457 doi "https://doi.org/10.1038/nature03492" @default.
• W2000425457 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1401489" @default.
• W2000425457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15829964" @default.
• W2000425457 hasPublicationYear "2005" @default.
• W2000425457 type Work @default.
• W2000425457 sameAs 2000425457 @default.
• W2000425457 citedByCount "131" @default.
• W2000425457 countsByYear W20004254572012 @default.
• W2000425457 countsByYear W20004254572013 @default.
• W2000425457 countsByYear W20004254572014 @default.
• W2000425457 countsByYear W20004254572015 @default.
• W2000425457 countsByYear W20004254572016 @default.
• W2000425457 countsByYear W20004254572017 @default.
• W2000425457 countsByYear W20004254572018 @default.
• W2000425457 countsByYear W20004254572019 @default.
• W2000425457 countsByYear W20004254572020 @default.
• W2000425457 countsByYear W20004254572021 @default.
• W2000425457 countsByYear W20004254572022 @default.
• W2000425457 crossrefType "journal-article" @default.
• W2000425457 hasAuthorship W2000425457A5026763137 @default.
• W2000425457 hasAuthorship W2000425457A5050409687 @default.
• W2000425457 hasAuthorship W2000425457A5056457864 @default.
• W2000425457 hasBestOaLocation W20004254572 @default.
• W2000425457 hasConcept C104317684 @default.
• W2000425457 hasConcept C121346293 @default.
• W2000425457 hasConcept C121608353 @default.
• W2000425457 hasConcept C140704245 @default.
• W2000425457 hasConcept C141231307 @default.
• W2000425457 hasConcept C159047783 @default.
• W2000425457 hasConcept C2522874641 @default.
• W2000425457 hasConcept C2778431562 @default.
• W2000425457 hasConcept C54355233 @default.
• W2000425457 hasConcept C555283112 @default.
• W2000425457 hasConcept C86803240 @default.
• W2000425457 hasConcept C97380033 @default.
• W2000425457 hasConceptScore W2000425457C104317684 @default.
• W2000425457 hasConceptScore W2000425457C121346293 @default.
• W2000425457 hasConceptScore W2000425457C121608353 @default.
• W2000425457 hasConceptScore W2000425457C140704245 @default.
• W2000425457 hasConceptScore W2000425457C141231307 @default.
• W2000425457 hasConceptScore W2000425457C159047783 @default.
• W2000425457 hasConceptScore W2000425457C2522874641 @default.
• W2000425457 hasConceptScore W2000425457C2778431562 @default.
• W2000425457 hasConceptScore W2000425457C54355233 @default.
• W2000425457 hasConceptScore W2000425457C555283112 @default.
• W2000425457 hasConceptScore W2000425457C86803240 @default.
• W2000425457 hasConceptScore W2000425457C97380033 @default.
• W2000425457 hasIssue "7035" @default.
• W2000425457 hasLocation W20004254571 @default.
• W2000425457 hasLocation W20004254572 @default.
• W2000425457 hasLocation W20004254573 @default.
• W2000425457 hasLocation W20004254574 @default.
• W2000425457 hasOpenAccess W2000425457 @default.
• W2000425457 hasPrimaryLocation W20004254571 @default.
• W2000425457 hasRelatedWork W1991126365 @default.
• W2000425457 hasRelatedWork W1996120444 @default.
• W2000425457 hasRelatedWork W2007879674 @default.
• W2000425457 hasRelatedWork W2054667493 @default.
• W2000425457 hasRelatedWork W2083392740 @default.
• W2000425457 hasRelatedWork W2087289607 @default.
• W2000425457 hasRelatedWork W2102513350 @default.
• W2000425457 hasRelatedWork W2145085007 @default.
• W2000425457 hasRelatedWork W2302345710 @default.
• W2000425457 hasRelatedWork W4240433125 @default.
• W2000425457 hasVolume "434" @default.
• W2000425457 isParatext "false" @default.

• next