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- W2000425555 abstract "Although useful for diagnosis of coronary disease, the ability of single photon emission computerized tomography (SPECT) to quantify infarct size (IS) is not well defined. Ten min after 2 mCi of intravenous Tl-201, 30 30-sec projections were obtained over 180° in 6 normal (nl) dogs and 10 other dogs 8 hours after closed-chest coronary occlusion (LAD in 7 and LCX in 3). After sacrifice, hearts were sliced and stained by triphenyl tetrazolium chloride (TTC). Pathologic IS was calculated on each slice and for the entire left ventricular myocardium (LV) as % weight. 0.4 cm-thick reconstructed oblique tomograms were quantified by automatic 60-point maximum count circumferential profile analysis, and computerized comparison of each point's activity to nl limit values derived from the 6 nl dogs. SPECT IS on each individual tomogram was defined as the % of circumferential points over the myocardial periphery falling below nl. SPECT and TTC IS on 62 corresponding slices with infarct correlated highly (mean±SD: 33±30 vs. 34±28, respectively, r=.87, p < .001). In order to obtain SPECT IS as % total LV, IS on each individual slice was multiplied by a different weighing factor depending on the depth of the SPECT slice along the long axis of the LV and values were subsequently added for the entire LV. SPECT and TTC IS for the entire LV also correlated highly (mean±SD: 20±8 vs. 22±7, respectively, r=0.87, p<0.01). Thus, computerized automatic analysis of SPECT T1–201 myocardial images is a valid method for the noninvasive assessment of the extent of myocardial infarction and thus may become a powerful prognostic indicator in ischemic heart disease." @default.
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- W2000425555 date "1984-09-01" @default.
- W2000425555 modified "2023-09-26" @default.
- W2000425555 title "QUANTIFICATION OF MYOCARDIAL INFARCT SIZE USING SINGLE PHOTON EMISSION COMPUTERIZED TOMOGRAPHY" @default.
- W2000425555 doi "https://doi.org/10.1097/00003072-198409001-00061" @default.
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