FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000425975> ?p ?o ?g. }

• W2000425975 endingPage "e67747" @default.
• W2000425975 startingPage "e67747" @default.
• W2000425975 abstract "The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal models of cardiac disorders are translatable to human disease. Mitochondria were rapidly isolated from fresh atrial tissue samples obtained from 14 patients undergoing Maze surgery due to atrial fibrillation. Human heart mitochondria exhibited typical mPT characteristics upon calcium overload such as swelling, evaluated by changes in light scattering, inhibition of respiration and loss of respiratory coupling. Swelling was a morphologically reversible event following transient calcium challenge. Calcium retention capacity (CRC), a quantitative measure of mPT sensitivity assayed by following extramitochondrial [Ca(2+)] and changes in respiration during a continuous calcium infusion, was significantly increased by cyclophilin D (CypD) inhibitors. The thiol-reactive oxidant phenylarsine oxide sensitized mitochondria to calcium-induced mPT. Release of the pro-apoptotic intermembrane protein cytochrome c was increased after, but not before, calcium discharge and respiratory inhibition in the CRC assay. From the present study, we conclude that adult viable heart mitochondria have a CypD- and oxidant-regulated mPT. The findings support that inhibition of mPT may be a relevant pharmacological target in human cardiac disease and may underlie the beneficial effect of cyclosporin A in reperfusion injury." @default.
• W2000425975 created "2016-06-24" @default.
• W2000425975 creator A5006430479 @default.
• W2000425975 creator A5022606164 @default.
• W2000425975 creator A5042848220 @default.
• W2000425975 creator A5052032823 @default.
• W2000425975 creator A5053275966 @default.
• W2000425975 creator A5063104255 @default.
• W2000425975 creator A5084706287 @default.
• W2000425975 creator A5086142401 @default.
• W2000425975 date "2013-06-28" @default.
• W2000425975 modified "2023-09-26" @default.
• W2000425975 title "Functional and Pharmacological Characteristics of Permeability Transition in Isolated Human Heart Mitochondria" @default.
• W2000425975 cites W136635533 @default.
• W2000425975 cites W1480051253 @default.
• W2000425975 cites W1489283017 @default.
• W2000425975 cites W1500536335 @default.
• W2000425975 cites W1507410890 @default.
• W2000425975 cites W1535995443 @default.
• W2000425975 cites W1567313097 @default.
• W2000425975 cites W1574721503 @default.
• W2000425975 cites W1767614014 @default.
• W2000425975 cites W1965355038 @default.
• W2000425975 cites W1966038248 @default.
• W2000425975 cites W1968112618 @default.
• W2000425975 cites W1972733192 @default.
• W2000425975 cites W1976389464 @default.
• W2000425975 cites W1977598374 @default.
• W2000425975 cites W1980697325 @default.
• W2000425975 cites W1984754431 @default.
• W2000425975 cites W1985586004 @default.
• W2000425975 cites W1991490958 @default.
• W2000425975 cites W1993322011 @default.
• W2000425975 cites W1993381147 @default.
• W2000425975 cites W1993849345 @default.
• W2000425975 cites W1996867825 @default.
• W2000425975 cites W1997795490 @default.
• W2000425975 cites W1998328762 @default.
• W2000425975 cites W2006925676 @default.
• W2000425975 cites W2009574988 @default.
• W2000425975 cites W2017094200 @default.
• W2000425975 cites W2021129026 @default.
• W2000425975 cites W2029077404 @default.
• W2000425975 cites W2032464570 @default.
• W2000425975 cites W2035202593 @default.
• W2000425975 cites W2037676584 @default.
• W2000425975 cites W2050769762 @default.
• W2000425975 cites W2058128468 @default.
• W2000425975 cites W2063385957 @default.
• W2000425975 cites W2074800090 @default.
• W2000425975 cites W2075957528 @default.
• W2000425975 cites W2077209766 @default.
• W2000425975 cites W2087616832 @default.
• W2000425975 cites W2091683736 @default.
• W2000425975 cites W2096378343 @default.
• W2000425975 cites W2109686719 @default.
• W2000425975 cites W2127864583 @default.
• W2000425975 cites W2134545202 @default.
• W2000425975 cites W2147549945 @default.
• W2000425975 cites W2148546947 @default.
• W2000425975 cites W2151482910 @default.
• W2000425975 cites W2153298328 @default.
• W2000425975 cites W2166209270 @default.
• W2000425975 cites W2235618496 @default.
• W2000425975 cites W31761959 @default.
• W2000425975 cites W4256022828 @default.
• W2000425975 doi "https://doi.org/10.1371/journal.pone.0067747" @default.
• W2000425975 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3695980" @default.
• W2000425975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23840770" @default.
• W2000425975 hasPublicationYear "2013" @default.
• W2000425975 type Work @default.
• W2000425975 sameAs 2000425975 @default.
• W2000425975 citedByCount "14" @default.
• W2000425975 countsByYear W20004259752013 @default.
• W2000425975 countsByYear W20004259752015 @default.
• W2000425975 countsByYear W20004259752016 @default.
• W2000425975 countsByYear W20004259752017 @default.
• W2000425975 countsByYear W20004259752018 @default.
• W2000425975 countsByYear W20004259752019 @default.
• W2000425975 countsByYear W20004259752020 @default.
• W2000425975 countsByYear W20004259752021 @default.
• W2000425975 countsByYear W20004259752022 @default.
• W2000425975 crossrefType "journal-article" @default.
• W2000425975 hasAuthorship W2000425975A5006430479 @default.
• W2000425975 hasAuthorship W2000425975A5022606164 @default.
• W2000425975 hasAuthorship W2000425975A5042848220 @default.
• W2000425975 hasAuthorship W2000425975A5052032823 @default.
• W2000425975 hasAuthorship W2000425975A5053275966 @default.
• W2000425975 hasAuthorship W2000425975A5063104255 @default.
• W2000425975 hasAuthorship W2000425975A5084706287 @default.
• W2000425975 hasAuthorship W2000425975A5086142401 @default.
• W2000425975 hasBestOaLocation W20004259751 @default.
• W2000425975 hasConcept C126322002 @default.
• W2000425975 hasConcept C13591479 @default.
• W2000425975 hasConcept C170493617 @default.
• W2000425975 hasConcept C185592680 @default.
• W2000425975 hasConcept C190283241 @default.
• W2000425975 hasConcept C2781161309 @default.

• next