Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000426321> ?p ?o ?g. }
- W2000426321 endingPage "792" @default.
- W2000426321 startingPage "785" @default.
- W2000426321 abstract "In the last few years, several studies have provided a causal link between constitutive activation of nuclear factor kappa-B (NF-kappaB) and the initiation and development of cancer. More recently, it appears that a cancer-induced inflammatory response may be an important factor in the inter-individual variability of the response to and toxic effects of cancer chemotherapy, as well as in the alteration of drug metabolism enzyme expression in patients. The relationships between chronic inflammation (or infection), cancer and drug metabolism are many: chronic infections lead to inflammation, inflammation may lead to cancer, cancer usually leads to an inflammatory syndrome, and inflammation alters the expression of drug metabolising enzymes and thus of the efficiency of cancer chemotherapy. This review focuses on the functional consequences of NF-kappaB activation during oncogenesis and on the expression of the major cytochrome P450s (CYP) involved in anticancer therapies. Finally, the potential role of NF-kappaB as the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer is discussed." @default.
- W2000426321 created "2016-06-24" @default.
- W2000426321 creator A5007151822 @default.
- W2000426321 creator A5025780107 @default.
- W2000426321 creator A5028772377 @default.
- W2000426321 creator A5039119608 @default.
- W2000426321 creator A5046103946 @default.
- W2000426321 date "2006-04-01" @default.
- W2000426321 modified "2023-10-17" @default.
- W2000426321 title "Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?" @default.
- W2000426321 cites W1501881225 @default.
- W2000426321 cites W1522455546 @default.
- W2000426321 cites W1558367558 @default.
- W2000426321 cites W174751373 @default.
- W2000426321 cites W1887243203 @default.
- W2000426321 cites W1924733673 @default.
- W2000426321 cites W1925943257 @default.
- W2000426321 cites W1965037168 @default.
- W2000426321 cites W1972692051 @default.
- W2000426321 cites W1972952746 @default.
- W2000426321 cites W1975372331 @default.
- W2000426321 cites W1976382352 @default.
- W2000426321 cites W1977727122 @default.
- W2000426321 cites W1980440732 @default.
- W2000426321 cites W1986242902 @default.
- W2000426321 cites W1987183940 @default.
- W2000426321 cites W1991739587 @default.
- W2000426321 cites W1991868611 @default.
- W2000426321 cites W1995287920 @default.
- W2000426321 cites W2000997921 @default.
- W2000426321 cites W2006774917 @default.
- W2000426321 cites W2007456673 @default.
- W2000426321 cites W2010237936 @default.
- W2000426321 cites W2011007912 @default.
- W2000426321 cites W2011137750 @default.
- W2000426321 cites W2011924809 @default.
- W2000426321 cites W2015625787 @default.
- W2000426321 cites W2031906032 @default.
- W2000426321 cites W2038780899 @default.
- W2000426321 cites W2040874631 @default.
- W2000426321 cites W2042763169 @default.
- W2000426321 cites W2043892945 @default.
- W2000426321 cites W2046056065 @default.
- W2000426321 cites W2048947831 @default.
- W2000426321 cites W2055177700 @default.
- W2000426321 cites W2056955574 @default.
- W2000426321 cites W2065279732 @default.
- W2000426321 cites W2065804207 @default.
- W2000426321 cites W2065835952 @default.
- W2000426321 cites W2071212514 @default.
- W2000426321 cites W2074564761 @default.
- W2000426321 cites W2075174614 @default.
- W2000426321 cites W2075340435 @default.
- W2000426321 cites W2076743940 @default.
- W2000426321 cites W2079879922 @default.
- W2000426321 cites W2080070482 @default.
- W2000426321 cites W2085944780 @default.
- W2000426321 cites W2087872766 @default.
- W2000426321 cites W2088905899 @default.
- W2000426321 cites W2091854189 @default.
- W2000426321 cites W2092839327 @default.
- W2000426321 cites W2094764170 @default.
- W2000426321 cites W2105683481 @default.
- W2000426321 cites W2105866978 @default.
- W2000426321 cites W2106109834 @default.
- W2000426321 cites W2106877484 @default.
- W2000426321 cites W2110114520 @default.
- W2000426321 cites W2111987150 @default.
- W2000426321 cites W2114756989 @default.
- W2000426321 cites W2116554142 @default.
- W2000426321 cites W2123101763 @default.
- W2000426321 cites W2124076790 @default.
- W2000426321 cites W2130482724 @default.
- W2000426321 cites W2134055375 @default.
- W2000426321 cites W2139666950 @default.
- W2000426321 cites W2139959086 @default.
- W2000426321 cites W2141100586 @default.
- W2000426321 cites W2146956879 @default.
- W2000426321 cites W2147921405 @default.
- W2000426321 cites W2148083393 @default.
- W2000426321 cites W2158110584 @default.
- W2000426321 cites W2159722075 @default.
- W2000426321 cites W2160740567 @default.
- W2000426321 cites W2161863099 @default.
- W2000426321 cites W2170081256 @default.
- W2000426321 cites W2317184793 @default.
- W2000426321 cites W2331176038 @default.
- W2000426321 cites W2335114990 @default.
- W2000426321 cites W2470223656 @default.
- W2000426321 cites W2745938442 @default.
- W2000426321 cites W4229648191 @default.
- W2000426321 cites W4235886171 @default.
- W2000426321 cites W4238352038 @default.
- W2000426321 cites W4247063789 @default.
- W2000426321 cites W432228268 @default.
- W2000426321 doi "https://doi.org/10.1016/j.ejca.2006.01.005" @default.
- W2000426321 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16510279" @default.
- W2000426321 hasPublicationYear "2006" @default.