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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000426326> ?p ?o ?g. }

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• W2000426326 abstract "The entire genome is replicated in a programmed manner, with specific regions undergoing DNA synthesis at different times in S phase. Active genes generally replicate in early S phase, while repressed genes replicate late, and for some loci this process is developmentally regulated. Using a nuclear microinjection system, we demonstrate that DNA sequences originally packaged into nucleosomes containing deacetylated histones during late S become reassembled with acetylated histones after undergoing replication in early S. Conversely, a change from early to late replication timing is accompanied by repackaging into nucleosomes containing deacetylated histones. This is carried out by differential cell-cycle-controlled acetylation and deacetylation of histones H3 and H4. These studies provide strong evidence that switches in replication timing may play a role in the regulation of nucleosome structure during development." @default.
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• W2000426326 date "2009-06-01" @default.
• W2000426326 modified "2023-10-16" @default.
• W2000426326 title "Shifts in Replication Timing Actively Affect Histone Acetylation during Nucleosome Reassembly" @default.
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• W2000426326 doi "https://doi.org/10.1016/j.molcel.2009.05.027" @default.
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