FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000426354> ?p ?o ?g. }

• W2000426354 endingPage "598" @default.
• W2000426354 startingPage "589" @default.
• W2000426354 abstract "Development of the germline requires the specification and survival of primordial germ cells (PGCs) in the embryo as well as the maintenance of gamete production during the reproductive life of the adult. These processes appear to be fundamental to all Metazoans, and some components of the genetic pathway regulating germ cell development and function are evolutionarily conserved. In both vertebrates and invertebrates, nanos-related genes, which encode RNA-binding zinc finger proteins, have been shown to play essential and conserved roles during germ cell formation. In Drosophila, maternally supplied nanos is required for survival of PGCs in the embryo, while in adults, nanos is required for the continued production of oocytes by maintaining germline stem cells self-renewal. In mice and zebrafish, nanos orthologs are required for PGC survival during embryogenesis, but a role in adults has not been explored. We show here that nanos1 in zebrafish is expressed in early stage oocytes in the adult female germline. We have identified a mutation in nanos1 using a reverse genetics method and show that young female nanos mutants contain oocytes, but fail to maintain oocyte production. This progressive loss of fertility in homozygous females is not a phenotype that has been described previously in the zebrafish and underlines the value of a reverse genetics approach in this model system." @default.
• W2000426354 created "2016-06-24" @default.
• W2000426354 creator A5040710180 @default.
• W2000426354 creator A5054139706 @default.
• W2000426354 creator A5082715439 @default.
• W2000426354 date "2007-05-01" @default.
• W2000426354 modified "2023-10-17" @default.
• W2000426354 title "nanos1 is required to maintain oocyte production in adult zebrafish" @default.
• W2000426354 cites W1505671001 @default.
• W2000426354 cites W1516768294 @default.
• W2000426354 cites W1527279107 @default.
• W2000426354 cites W1600642794 @default.
• W2000426354 cites W1888475523 @default.
• W2000426354 cites W1920770960 @default.
• W2000426354 cites W1972812055 @default.
• W2000426354 cites W1984535701 @default.
• W2000426354 cites W2009129140 @default.
• W2000426354 cites W2009553579 @default.
• W2000426354 cites W2014908429 @default.
• W2000426354 cites W2018632741 @default.
• W2000426354 cites W2025635760 @default.
• W2000426354 cites W2028633196 @default.
• W2000426354 cites W2031853229 @default.
• W2000426354 cites W2042853239 @default.
• W2000426354 cites W2043495620 @default.
• W2000426354 cites W2046610092 @default.
• W2000426354 cites W2047247552 @default.
• W2000426354 cites W2049255037 @default.
• W2000426354 cites W2051401308 @default.
• W2000426354 cites W2052374677 @default.
• W2000426354 cites W2073918293 @default.
• W2000426354 cites W2078724155 @default.
• W2000426354 cites W2087176961 @default.
• W2000426354 cites W2090051522 @default.
• W2000426354 cites W2090453380 @default.
• W2000426354 cites W2092205297 @default.
• W2000426354 cites W2111069555 @default.
• W2000426354 cites W2115183068 @default.
• W2000426354 cites W2117936467 @default.
• W2000426354 cites W2121350246 @default.
• W2000426354 cites W2125349610 @default.
• W2000426354 cites W2126036680 @default.
• W2000426354 cites W2129827413 @default.
• W2000426354 cites W2133007496 @default.
• W2000426354 cites W2133231617 @default.
• W2000426354 cites W2135704151 @default.
• W2000426354 cites W2145721017 @default.
• W2000426354 cites W2150014745 @default.
• W2000426354 cites W2164386538 @default.
• W2000426354 cites W2166508718 @default.
• W2000426354 cites W2266093504 @default.
• W2000426354 cites W4236272075 @default.
• W2000426354 doi "https://doi.org/10.1016/j.ydbio.2007.03.007" @default.
• W2000426354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1986726" @default.
• W2000426354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17418113" @default.
• W2000426354 hasPublicationYear "2007" @default.
• W2000426354 type Work @default.
• W2000426354 sameAs 2000426354 @default.
• W2000426354 citedByCount "147" @default.
• W2000426354 countsByYear W20004263542012 @default.
• W2000426354 countsByYear W20004263542013 @default.
• W2000426354 countsByYear W20004263542014 @default.
• W2000426354 countsByYear W20004263542015 @default.
• W2000426354 countsByYear W20004263542016 @default.
• W2000426354 countsByYear W20004263542017 @default.
• W2000426354 countsByYear W20004263542018 @default.
• W2000426354 countsByYear W20004263542019 @default.
• W2000426354 countsByYear W20004263542020 @default.
• W2000426354 countsByYear W20004263542021 @default.
• W2000426354 countsByYear W20004263542022 @default.
• W2000426354 countsByYear W20004263542023 @default.
• W2000426354 crossrefType "journal-article" @default.
• W2000426354 hasAuthorship W2000426354A5040710180 @default.
• W2000426354 hasAuthorship W2000426354A5054139706 @default.
• W2000426354 hasAuthorship W2000426354A5082715439 @default.
• W2000426354 hasBestOaLocation W20004263541 @default.
• W2000426354 hasConcept C104317684 @default.
• W2000426354 hasConcept C109825262 @default.
• W2000426354 hasConcept C127716648 @default.
• W2000426354 hasConcept C196843134 @default.
• W2000426354 hasConcept C2776690073 @default.
• W2000426354 hasConcept C2776803348 @default.
• W2000426354 hasConcept C2776878037 @default.
• W2000426354 hasConcept C2779122487 @default.
• W2000426354 hasConcept C2781087480 @default.
• W2000426354 hasConcept C54355233 @default.
• W2000426354 hasConcept C86803240 @default.
• W2000426354 hasConcept C95444343 @default.
• W2000426354 hasConceptScore W2000426354C104317684 @default.
• W2000426354 hasConceptScore W2000426354C109825262 @default.
• W2000426354 hasConceptScore W2000426354C127716648 @default.
• W2000426354 hasConceptScore W2000426354C196843134 @default.
• W2000426354 hasConceptScore W2000426354C2776690073 @default.
• W2000426354 hasConceptScore W2000426354C2776803348 @default.
• W2000426354 hasConceptScore W2000426354C2776878037 @default.
• W2000426354 hasConceptScore W2000426354C2779122487 @default.
• W2000426354 hasConceptScore W2000426354C2781087480 @default.
• W2000426354 hasConceptScore W2000426354C54355233 @default.

• next