Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000428412> ?p ?o ?g. }
- W2000428412 endingPage "397" @default.
- W2000428412 startingPage "392" @default.
- W2000428412 abstract "We have previously shown that bacterially expressed p53 protein or p53 protein isolated from cis-diamminedichloroplatinum II (cisplatin)-damaged cells is capable of binding to double-stranded platinated DNA molecules lacking any p53 DNA binding sites. Here we report using various p53 mutants that two separate domains of p53 protein affect p53 binding to platinated DNA. Mutations within the central core of p53, the domain responsible for sequence-specific DNA binding activity, completely eliminated p53 binding to platinated DNA. Based on competition experiments p53 preferred binding to sequence-specific DNA molecules over platinated DNA molecules. However, p53 binding to platinated DNA molecules was significantly stronger than p53 interactions with DNA molecules lacking damage and a p53 consensus site. Finally, an antibody specific to the C-terminal domain of p53 (pAb421) which activates sequence-specific DNA binding activity inhibited p53 binding to platinated DNA. Taken together, these results suggest that in addition to binding to p53 DNA binding sites, p53 also interacts with cisplatin-damaged DNA molecules." @default.
- W2000428412 created "2016-06-24" @default.
- W2000428412 creator A5021106921 @default.
- W2000428412 creator A5021856558 @default.
- W2000428412 date "2001-02-01" @default.
- W2000428412 modified "2023-10-16" @default.
- W2000428412 title "p53 binds to cisplatin-damaged DNA" @default.
- W2000428412 cites W1498714987 @default.
- W2000428412 cites W1528710182 @default.
- W2000428412 cites W1657827244 @default.
- W2000428412 cites W1849359401 @default.
- W2000428412 cites W1927421238 @default.
- W2000428412 cites W1952836109 @default.
- W2000428412 cites W1963679580 @default.
- W2000428412 cites W1977468760 @default.
- W2000428412 cites W1980655006 @default.
- W2000428412 cites W1983386156 @default.
- W2000428412 cites W1986179131 @default.
- W2000428412 cites W1993831923 @default.
- W2000428412 cites W1995856480 @default.
- W2000428412 cites W1996899753 @default.
- W2000428412 cites W2001003817 @default.
- W2000428412 cites W2003236156 @default.
- W2000428412 cites W2004863907 @default.
- W2000428412 cites W2006607764 @default.
- W2000428412 cites W2013136213 @default.
- W2000428412 cites W2014644281 @default.
- W2000428412 cites W2015314126 @default.
- W2000428412 cites W2015519364 @default.
- W2000428412 cites W2022762967 @default.
- W2000428412 cites W2064308761 @default.
- W2000428412 cites W2064795157 @default.
- W2000428412 cites W2068691401 @default.
- W2000428412 cites W2081446097 @default.
- W2000428412 cites W2089218510 @default.
- W2000428412 cites W2092722802 @default.
- W2000428412 cites W2122059211 @default.
- W2000428412 cites W2128583894 @default.
- W2000428412 cites W2150710841 @default.
- W2000428412 cites W2168833834 @default.
- W2000428412 doi "https://doi.org/10.1016/s0167-4781(00)00305-5" @default.
- W2000428412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11342217" @default.
- W2000428412 hasPublicationYear "2001" @default.
- W2000428412 type Work @default.
- W2000428412 sameAs 2000428412 @default.
- W2000428412 citedByCount "32" @default.
- W2000428412 countsByYear W20004284122012 @default.
- W2000428412 countsByYear W20004284122014 @default.
- W2000428412 countsByYear W20004284122015 @default.
- W2000428412 countsByYear W20004284122016 @default.
- W2000428412 countsByYear W20004284122017 @default.
- W2000428412 countsByYear W20004284122018 @default.
- W2000428412 countsByYear W20004284122019 @default.
- W2000428412 countsByYear W20004284122022 @default.
- W2000428412 countsByYear W20004284122023 @default.
- W2000428412 crossrefType "journal-article" @default.
- W2000428412 hasAuthorship W2000428412A5021106921 @default.
- W2000428412 hasAuthorship W2000428412A5021856558 @default.
- W2000428412 hasConcept C101762097 @default.
- W2000428412 hasConcept C104317684 @default.
- W2000428412 hasConcept C107824862 @default.
- W2000428412 hasConcept C143425029 @default.
- W2000428412 hasConcept C150194340 @default.
- W2000428412 hasConcept C153911025 @default.
- W2000428412 hasConcept C156569929 @default.
- W2000428412 hasConcept C25166345 @default.
- W2000428412 hasConcept C2776694085 @default.
- W2000428412 hasConcept C2778239845 @default.
- W2000428412 hasConcept C33987129 @default.
- W2000428412 hasConcept C3662595 @default.
- W2000428412 hasConcept C5179208 @default.
- W2000428412 hasConcept C54355233 @default.
- W2000428412 hasConcept C552990157 @default.
- W2000428412 hasConcept C55493867 @default.
- W2000428412 hasConcept C86339819 @default.
- W2000428412 hasConcept C86803240 @default.
- W2000428412 hasConcept C94966510 @default.
- W2000428412 hasConceptScore W2000428412C101762097 @default.
- W2000428412 hasConceptScore W2000428412C104317684 @default.
- W2000428412 hasConceptScore W2000428412C107824862 @default.
- W2000428412 hasConceptScore W2000428412C143425029 @default.
- W2000428412 hasConceptScore W2000428412C150194340 @default.
- W2000428412 hasConceptScore W2000428412C153911025 @default.
- W2000428412 hasConceptScore W2000428412C156569929 @default.
- W2000428412 hasConceptScore W2000428412C25166345 @default.
- W2000428412 hasConceptScore W2000428412C2776694085 @default.
- W2000428412 hasConceptScore W2000428412C2778239845 @default.
- W2000428412 hasConceptScore W2000428412C33987129 @default.
- W2000428412 hasConceptScore W2000428412C3662595 @default.
- W2000428412 hasConceptScore W2000428412C5179208 @default.
- W2000428412 hasConceptScore W2000428412C54355233 @default.
- W2000428412 hasConceptScore W2000428412C552990157 @default.
- W2000428412 hasConceptScore W2000428412C55493867 @default.
- W2000428412 hasConceptScore W2000428412C86339819 @default.
- W2000428412 hasConceptScore W2000428412C86803240 @default.
- W2000428412 hasConceptScore W2000428412C94966510 @default.
- W2000428412 hasIssue "3" @default.
- W2000428412 hasLocation W20004284121 @default.