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• W2000429439 abstract "Absorption of food allergens from the intestinal tract is thought to be important in the development of food allergies. A recent report showed that intestinal permeability to macromolecules was increased in patients with adverse reactions to food [ [1] Ventura M.T. Polimeno L. Amoruso A.C. Gatti F. Annoscia E. Marinaro M. et al. Intestinal permeability in patients with adverse reactions to food. Dig Liver Dis. 2006; 38: 732-736 Abstract Full Text Full Text PDF PubMed Scopus (110) Google Scholar ]. Passage of intact dietary allergens, such as β-lactoglobulin and ovalbumin in meal, into the blood has been documented [ [2] Husby S. Jensenius J.C. Svehag S.E. Passage of undegraded dietary antigen into the blood of healthy adults. Further characterization of the kinetics of uptake and the size distribution of the antigen. Scand J Immunol. 1986; 24: 447-455 Crossref PubMed Scopus (80) Google Scholar ]. In our previous study, we demonstrated that the circulating levels of gliadin, which is recognized as an allergen for a variety of wheat allergies, were correlated with the clinical symptoms in patients with wheat-dependent exercise-induced anaphylaxis (WDEIA) [ 3 Matsuo H. Morimoto K. Akaki T. Kaneko S. Kusatake K. Kuroda T. et al. Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis. Clin Exp Allergy. 2005; 35: 461-466 Crossref PubMed Scopus (219) Google Scholar , 4 Morita E. Kunie K. Matsuo H. Food-dependent exercise-induced anaphylaxis. J Dermatol Sci. 2007; 47: 109-117 Abstract Full Text Full Text PDF PubMed Scopus (191) Google Scholar ]. Interestingly, increased serum gliadin levels induced by exercise and aspirin were also observed in healthy subjects. In addition, a recent case report described a patient with WDEIA induced by low-dose aspirin therapy for secondary prevention of cardiovascular events [ [5] Fujii H. Kambe N. Fujisawa A. Kohno K. Morita E. Miyachi Y. Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy. Allergol Int. 2008; 57: 97-98 Crossref PubMed Scopus (50) Google Scholar ]. Intake of aspirin enhances intestinal permeability, which is associated with gastrointestinal disorders [ [6] Lambert G.P. Boylan M. Laventure J.P. Bull A. Lanspa S. Effect of aspirin and ibuprofen on GI permeability during exercise. Int J Sports Med. 2007; 28: 722-726 Crossref PubMed Scopus (56) Google Scholar ]. Thus, it is hypothesized that aspirin facilitates the absorption of intact gliadin due to an increase in gastrointestinal permeability. However, the dose effects of aspirin and administration of other non-steroidal anti-inflammatory drugs (NSAIDs) on the absorption of wheat gliadin remain unclear. The purpose of the present study was to evaluate the effects of administration of low-dose aspirin and conventional-dose of diclofenac, loxoprofen and meloxicam on serum gliadin levels after wheat ingestion in healthy subjects." @default.
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• W2000429439 date "2009-03-01" @default.
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• W2000429439 title "Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on serum allergen levels after wheat ingestion" @default.
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• W2000429439 doi "https://doi.org/10.1016/j.jdermsci.2008.09.004" @default.
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