FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000429688> ?p ?o ?g. }

• W2000429688 endingPage "709" @default.
• W2000429688 startingPage "701" @default.
• W2000429688 abstract "Endothelial microparticles (EMPs) are irregularly shaped membrane fragments shed into the circulation in patients with vascular diseases, and may themselves act to enhance the endothelial response to inflammation. On the basis of the importance of p38 mitogen-activated protein kinase (MAPK) in endothelial responses to inflammatory stimuli, we sought to define the role of p38 in EMP generation and function.Microparticle generation from cultures of human aortic endothelial cells (hAECs) treated with tumor necrosis factor-alpha (TNF-alpha) and p38 inhibition was quantified via multiple modalities. The response of target endothelial cells was assessed by treatment of cells with EMPs generated under various conditions.Inhibition of p38 in hAECs, using pharmacologic agents, resulted in a 50% reduction of TNF-alpha-induced EMPs. Importantly, suppression of microparticles was specific to p38 MAPK pathways. EMPs triggered by TNF-alpha activation induced an approximately four-fold increase in soluble intercellular adhesion molecule-1 (sICAM-1) release from targeted cells. However, inhibition of p38 MAPK in the targeted cell prior to EMP treatment did not alter the sICAM1 response.Our findings implicate p38 MAPK signaling as significant and selective in the formation and maturation of EMPs. EMPs elicited a proinflammatory response from targeted hAECs that was dependent on the conditions under which EMPs were generated. However, our results imply a unidirectional model in which p38 MAPK is critical at the source of microparticle formation, but not the target cell response to EMPs. These findings indicate a novel mechanism by which p38 inhibition may offer therapeutic benefit in vivo via direct inhibition of EMP formation." @default.
• W2000429688 created "2016-06-24" @default.
• W2000429688 creator A5023169167 @default.
• W2000429688 creator A5029884137 @default.
• W2000429688 creator A5044601059 @default.
• W2000429688 creator A5064256529 @default.
• W2000429688 creator A5085022080 @default.
• W2000429688 creator A5085167417 @default.
• W2000429688 date "2009-04-01" @default.
• W2000429688 modified "2023-09-30" @default.
• W2000429688 title "p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles" @default.
• W2000429688 cites W1854796791 @default.
• W2000429688 cites W1972365386 @default.
• W2000429688 cites W1974267201 @default.
• W2000429688 cites W1978685100 @default.
• W2000429688 cites W1985225188 @default.
• W2000429688 cites W2003548212 @default.
• W2000429688 cites W2004653956 @default.
• W2000429688 cites W2007306221 @default.
• W2000429688 cites W2021861291 @default.
• W2000429688 cites W2028151586 @default.
• W2000429688 cites W2030383998 @default.
• W2000429688 cites W2031930036 @default.
• W2000429688 cites W2042274679 @default.
• W2000429688 cites W2053642376 @default.
• W2000429688 cites W2054792986 @default.
• W2000429688 cites W2056445309 @default.
• W2000429688 cites W2069887689 @default.
• W2000429688 cites W2079949057 @default.
• W2000429688 cites W2084908356 @default.
• W2000429688 cites W2085883586 @default.
• W2000429688 cites W2086062763 @default.
• W2000429688 cites W2086275775 @default.
• W2000429688 cites W2109306753 @default.
• W2000429688 cites W2113837700 @default.
• W2000429688 cites W2116643762 @default.
• W2000429688 cites W2117486867 @default.
• W2000429688 cites W2137742067 @default.
• W2000429688 cites W2142902782 @default.
• W2000429688 cites W2152378595 @default.
• W2000429688 cites W2153982586 @default.
• W2000429688 cites W2156887090 @default.
• W2000429688 cites W2163625494 @default.
• W2000429688 doi "https://doi.org/10.1111/j.1538-7836.2009.03304.x" @default.
• W2000429688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19192109" @default.
• W2000429688 hasPublicationYear "2009" @default.
• W2000429688 type Work @default.
• W2000429688 sameAs 2000429688 @default.
• W2000429688 citedByCount "106" @default.
• W2000429688 countsByYear W20004296882012 @default.
• W2000429688 countsByYear W20004296882013 @default.
• W2000429688 countsByYear W20004296882014 @default.
• W2000429688 countsByYear W20004296882015 @default.
• W2000429688 countsByYear W20004296882016 @default.
• W2000429688 countsByYear W20004296882017 @default.
• W2000429688 countsByYear W20004296882018 @default.
• W2000429688 countsByYear W20004296882019 @default.
• W2000429688 countsByYear W20004296882020 @default.
• W2000429688 countsByYear W20004296882021 @default.
• W2000429688 countsByYear W20004296882022 @default.
• W2000429688 countsByYear W20004296882023 @default.
• W2000429688 crossrefType "journal-article" @default.
• W2000429688 hasAuthorship W2000429688A5023169167 @default.
• W2000429688 hasAuthorship W2000429688A5029884137 @default.
• W2000429688 hasAuthorship W2000429688A5044601059 @default.
• W2000429688 hasAuthorship W2000429688A5064256529 @default.
• W2000429688 hasAuthorship W2000429688A5085022080 @default.
• W2000429688 hasAuthorship W2000429688A5085167417 @default.
• W2000429688 hasBestOaLocation W20004296881 @default.
• W2000429688 hasConcept C123012128 @default.
• W2000429688 hasConcept C164027704 @default.
• W2000429688 hasConcept C17991360 @default.
• W2000429688 hasConcept C184235292 @default.
• W2000429688 hasConcept C185592680 @default.
• W2000429688 hasConcept C202751555 @default.
• W2000429688 hasConcept C203014093 @default.
• W2000429688 hasConcept C2776914184 @default.
• W2000429688 hasConcept C502942594 @default.
• W2000429688 hasConcept C51551487 @default.
• W2000429688 hasConcept C55493867 @default.
• W2000429688 hasConcept C57074206 @default.
• W2000429688 hasConcept C86803240 @default.
• W2000429688 hasConcept C95444343 @default.
• W2000429688 hasConcept C97029542 @default.
• W2000429688 hasConceptScore W2000429688C123012128 @default.
• W2000429688 hasConceptScore W2000429688C164027704 @default.
• W2000429688 hasConceptScore W2000429688C17991360 @default.
• W2000429688 hasConceptScore W2000429688C184235292 @default.
• W2000429688 hasConceptScore W2000429688C185592680 @default.
• W2000429688 hasConceptScore W2000429688C202751555 @default.
• W2000429688 hasConceptScore W2000429688C203014093 @default.
• W2000429688 hasConceptScore W2000429688C2776914184 @default.
• W2000429688 hasConceptScore W2000429688C502942594 @default.
• W2000429688 hasConceptScore W2000429688C51551487 @default.
• W2000429688 hasConceptScore W2000429688C55493867 @default.
• W2000429688 hasConceptScore W2000429688C57074206 @default.
• W2000429688 hasConceptScore W2000429688C86803240 @default.
• W2000429688 hasConceptScore W2000429688C95444343 @default.

• next