FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000430596> ?p ?o ?g. }

• W2000430596 endingPage "460" @default.
• W2000430596 startingPage "449" @default.
• W2000430596 abstract "Peptidyl-prolyl cis/trans isomerisation has been frequently found as a rate limiting step in the folding of proteins. In order to determine whether the nature of the amino acid preceding proline controls the probability of cis prolyl bonds in native proteins, systematic studies on the thermodynamics and kinetics of the prolyl isomerisation in the pentapeptide series Ac-Ala-Xaa-Pro-Ala-Lys-NH2were performed. All proteinogenic amino acids were substituted in the position preceding proline. When measured by 1H-NMR and CD spectroscopy both isomers proved to be devoid of ordered structure in the whole series of the oligopeptides in aqueous solution. Thus, isomerization rates and cis/trans ratios calculated from solvent jump and 1H-NMR magnetisation transfer experiments exclusively reflect the side-chain effects of the Xaa position in the peptide series. There is a rough correlation between the cis content in the oligopeptides and the propensity of Xaa-Pro cis prolyl bonds in proteins. This correlation suggests that the prolyl bond conformation is mainly determined by local effects in proteins. The rate constants kc→tof pentapeptides containing unionised amino acids preceding proline range from 3.2×10−3 s−1 (Xaa=Ala) to 0.5×10−3 s−1 (Xaa=Trp) at 4°C. Proline clustering led to an isomerisation cycle indicating considerable influence on the isomerisation rates of the peptide bond conformations flanking the rotating bond. Both tyrosine and histidine specifically reduce isomerisation rates severalfold by deprotonation of their respective side-chains." @default.
• W2000430596 created "2016-06-24" @default.
• W2000430596 creator A5012574811 @default.
• W2000430596 creator A5023621154 @default.
• W2000430596 creator A5029466492 @default.
• W2000430596 creator A5058816586 @default.
• W2000430596 creator A5059281644 @default.
• W2000430596 creator A5075692819 @default.
• W2000430596 date "1998-06-01" @default.
• W2000430596 modified "2023-10-16" @default.
• W2000430596 title "Side-chain effects on peptidyl-prolyl cis/trans isomerisation" @default.
• W2000430596 cites W1039083189 @default.
• W2000430596 cites W117182952 @default.
• W2000430596 cites W1498798237 @default.
• W2000430596 cites W1544623810 @default.
• W2000430596 cites W1583655086 @default.
• W2000430596 cites W1588317987 @default.
• W2000430596 cites W1588439587 @default.
• W2000430596 cites W1608807138 @default.
• W2000430596 cites W1843397982 @default.
• W2000430596 cites W1872921923 @default.
• W2000430596 cites W1963550288 @default.
• W2000430596 cites W1964686357 @default.
• W2000430596 cites W1965819231 @default.
• W2000430596 cites W1973565326 @default.
• W2000430596 cites W1974790505 @default.
• W2000430596 cites W1975854921 @default.
• W2000430596 cites W1978892474 @default.
• W2000430596 cites W1983741980 @default.
• W2000430596 cites W1984640820 @default.
• W2000430596 cites W1996711229 @default.
• W2000430596 cites W1999548431 @default.
• W2000430596 cites W2003345672 @default.
• W2000430596 cites W2008156250 @default.
• W2000430596 cites W2011926767 @default.
• W2000430596 cites W2025743221 @default.
• W2000430596 cites W2030900141 @default.
• W2000430596 cites W2033416116 @default.
• W2000430596 cites W2034137054 @default.
• W2000430596 cites W2039519959 @default.
• W2000430596 cites W2041349943 @default.
• W2000430596 cites W2041900008 @default.
• W2000430596 cites W2043133671 @default.
• W2000430596 cites W2043823238 @default.
• W2000430596 cites W2045199665 @default.
• W2000430596 cites W2047572594 @default.
• W2000430596 cites W2049460124 @default.
• W2000430596 cites W2049790400 @default.
• W2000430596 cites W2056959896 @default.
• W2000430596 cites W2058669625 @default.
• W2000430596 cites W2064542810 @default.
• W2000430596 cites W2072219438 @default.
• W2000430596 cites W2077140822 @default.
• W2000430596 cites W2083753880 @default.
• W2000430596 cites W2085005694 @default.
• W2000430596 cites W2087016476 @default.
• W2000430596 cites W2088189057 @default.
• W2000430596 cites W2089058369 @default.
• W2000430596 cites W2090208503 @default.
• W2000430596 cites W2095169134 @default.
• W2000430596 cites W2109188826 @default.
• W2000430596 cites W2151252209 @default.
• W2000430596 cites W2164827586 @default.
• W2000430596 cites W216672338 @default.
• W2000430596 cites W2168211076 @default.
• W2000430596 cites W2176412414 @default.
• W2000430596 cites W2335377065 @default.
• W2000430596 cites W2411540165 @default.
• W2000430596 cites W4251209208 @default.
• W2000430596 doi "https://doi.org/10.1006/jmbi.1998.1770" @default.
• W2000430596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9642049" @default.
• W2000430596 hasPublicationYear "1998" @default.
• W2000430596 type Work @default.
• W2000430596 sameAs 2000430596 @default.
• W2000430596 citedByCount "324" @default.
• W2000430596 countsByYear W20004305962012 @default.
• W2000430596 countsByYear W20004305962013 @default.
• W2000430596 countsByYear W20004305962014 @default.
• W2000430596 countsByYear W20004305962015 @default.
• W2000430596 countsByYear W20004305962016 @default.
• W2000430596 countsByYear W20004305962017 @default.
• W2000430596 countsByYear W20004305962018 @default.
• W2000430596 countsByYear W20004305962019 @default.
• W2000430596 countsByYear W20004305962020 @default.
• W2000430596 countsByYear W20004305962021 @default.
• W2000430596 countsByYear W20004305962022 @default.
• W2000430596 countsByYear W20004305962023 @default.
• W2000430596 crossrefType "journal-article" @default.
• W2000430596 hasAuthorship W2000430596A5012574811 @default.
• W2000430596 hasAuthorship W2000430596A5023621154 @default.
• W2000430596 hasAuthorship W2000430596A5029466492 @default.
• W2000430596 hasAuthorship W2000430596A5058816586 @default.
• W2000430596 hasAuthorship W2000430596A5059281644 @default.
• W2000430596 hasAuthorship W2000430596A5075692819 @default.
• W2000430596 hasConcept C109300003 @default.
• W2000430596 hasConcept C126661725 @default.
• W2000430596 hasConcept C13935069 @default.
• W2000430596 hasConcept C161790260 @default.

• next