FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000430869> ?p ?o ?g. }

• W2000430869 endingPage "S214" @default.
• W2000430869 startingPage "S214" @default.
• W2000430869 abstract "Purpose/Objective(s)To examine factors associated with outcome in a racially diverse cohort of women with early breast cancer.Materials/Methods1055 women with Stage I (70%) or II (30%) breast cancer treated with breast conservation therapy (BCT) between 1984–2004 were analyzed using competing risks methods for cumulative incidence of LRF (locoregional failure), distant failure (DF), and mortality as first events. Backward stepwise Cox proportional hazards models were used to identify factors prognostic for overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). OS, DFS, and LRC were estimated using the Kaplan-Meier method. DFS time was defined as time to first LRF, DF, or death. The LRC definition censored deaths without LRF. Covariates for multivariate analysis (MVA) included age, weight, tumor size, node positive status, hormone receptor positive status, grade, chemotherapy use, margin status, black race, co-morbid diseases (CMD), and method of detection (clinical vs. mammographic). In the table, only covariates that reached statistical significance are shown.ResultsMedian follow-up was 81 months. Mean age was 60.8 years (range 40–91). 50% of the tumors were mammographically detected (Mdet). The mean size of Mdet tumors was 1.15 cm (black) vs. 1.18 cm (non-black) (p = .68). The 8-year (8Y) cumulative incidence (CI) of LRF was 3.9% for all patients (black-6.0%, non-black-3.2%, p = .069). The 8Y CI of DF was 5.1% (black-7.0%, non-black-4.4%, p = .47). The 8Y CI of intercurrent mortality was 10.6% (black-13.9%, non-black-9.4%, p = .007). 8Y DFS was 80.4% (black-73.1%, non-black-83.1%, p = .01). 8Y OS was 84.8% (black-80.1%, non-black 86.5%, p = .01).In the non-black population, Mdet was a favorable prognostic indicator for OS and DFS. However, in black patients, Mdet was not associated with improved OS or DFS in spite of virtually identical mean tumor size at detection (Table). MVA on the Mdet population revealed black race, node positive disease, co-morbid disease and increasing age to be statistically significantly associated with poor outcomes for OS (data not shown). Black race, CMD and increasing age were also statistically significantly associated with poor DFS. On analysis of patients with clinically detected tumors, race was not significant for OS (HR 1.05, 95% CI 0.67–1.65, p = .82) or DFS (HR 1.14, 95% CI 0.76–1.73, p = 0.52).ConclusionsTabled 1Overall survivalDisease free survivalMean sizeHR (95% CI)HR (95% CI)MdetCdetNon-black (NB)Mdet 0.53 (0.35–0.78)Mdet 0.68 (0.47–0.98)1.17 cm (All)1.83 cm (All)CMD 1.52 (1.02–2.27)CMD 1.44 (1.00–2.07)1.18 cm (NB)1.77 cm (NB)Inc. age 1.06 (1.04–1.08)Inc. age 1.04 (1.02–1.06)1.15 cm (B)1.85 cm (B)Inc. Wt 1.01 (1.00–1.02)p = 0.68p = .20Black (B)Inc. age 1.07 (1.03–1.07)Inc. age 1.05 (1.03–1.07) Open table in a new tab Purpose/Objective(s)To examine factors associated with outcome in a racially diverse cohort of women with early breast cancer. To examine factors associated with outcome in a racially diverse cohort of women with early breast cancer. Materials/Methods1055 women with Stage I (70%) or II (30%) breast cancer treated with breast conservation therapy (BCT) between 1984–2004 were analyzed using competing risks methods for cumulative incidence of LRF (locoregional failure), distant failure (DF), and mortality as first events. Backward stepwise Cox proportional hazards models were used to identify factors prognostic for overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). OS, DFS, and LRC were estimated using the Kaplan-Meier method. DFS time was defined as time to first LRF, DF, or death. The LRC definition censored deaths without LRF. Covariates for multivariate analysis (MVA) included age, weight, tumor size, node positive status, hormone receptor positive status, grade, chemotherapy use, margin status, black race, co-morbid diseases (CMD), and method of detection (clinical vs. mammographic). In the table, only covariates that reached statistical significance are shown. 1055 women with Stage I (70%) or II (30%) breast cancer treated with breast conservation therapy (BCT) between 1984–2004 were analyzed using competing risks methods for cumulative incidence of LRF (locoregional failure), distant failure (DF), and mortality as first events. Backward stepwise Cox proportional hazards models were used to identify factors prognostic for overall survival (OS), disease-free survival (DFS) and locoregional control (LRC). OS, DFS, and LRC were estimated using the Kaplan-Meier method. DFS time was defined as time to first LRF, DF, or death. The LRC definition censored deaths without LRF. Covariates for multivariate analysis (MVA) included age, weight, tumor size, node positive status, hormone receptor positive status, grade, chemotherapy use, margin status, black race, co-morbid diseases (CMD), and method of detection (clinical vs. mammographic). In the table, only covariates that reached statistical significance are shown. ResultsMedian follow-up was 81 months. Mean age was 60.8 years (range 40–91). 50% of the tumors were mammographically detected (Mdet). The mean size of Mdet tumors was 1.15 cm (black) vs. 1.18 cm (non-black) (p = .68). The 8-year (8Y) cumulative incidence (CI) of LRF was 3.9% for all patients (black-6.0%, non-black-3.2%, p = .069). The 8Y CI of DF was 5.1% (black-7.0%, non-black-4.4%, p = .47). The 8Y CI of intercurrent mortality was 10.6% (black-13.9%, non-black-9.4%, p = .007). 8Y DFS was 80.4% (black-73.1%, non-black-83.1%, p = .01). 8Y OS was 84.8% (black-80.1%, non-black 86.5%, p = .01).In the non-black population, Mdet was a favorable prognostic indicator for OS and DFS. However, in black patients, Mdet was not associated with improved OS or DFS in spite of virtually identical mean tumor size at detection (Table). MVA on the Mdet population revealed black race, node positive disease, co-morbid disease and increasing age to be statistically significantly associated with poor outcomes for OS (data not shown). Black race, CMD and increasing age were also statistically significantly associated with poor DFS. On analysis of patients with clinically detected tumors, race was not significant for OS (HR 1.05, 95% CI 0.67–1.65, p = .82) or DFS (HR 1.14, 95% CI 0.76–1.73, p = 0.52). Median follow-up was 81 months. Mean age was 60.8 years (range 40–91). 50% of the tumors were mammographically detected (Mdet). The mean size of Mdet tumors was 1.15 cm (black) vs. 1.18 cm (non-black) (p = .68). The 8-year (8Y) cumulative incidence (CI) of LRF was 3.9% for all patients (black-6.0%, non-black-3.2%, p = .069). The 8Y CI of DF was 5.1% (black-7.0%, non-black-4.4%, p = .47). The 8Y CI of intercurrent mortality was 10.6% (black-13.9%, non-black-9.4%, p = .007). 8Y DFS was 80.4% (black-73.1%, non-black-83.1%, p = .01). 8Y OS was 84.8% (black-80.1%, non-black 86.5%, p = .01). In the non-black population, Mdet was a favorable prognostic indicator for OS and DFS. However, in black patients, Mdet was not associated with improved OS or DFS in spite of virtually identical mean tumor size at detection (Table). MVA on the Mdet population revealed black race, node positive disease, co-morbid disease and increasing age to be statistically significantly associated with poor outcomes for OS (data not shown). Black race, CMD and increasing age were also statistically significantly associated with poor DFS. On analysis of patients with clinically detected tumors, race was not significant for OS (HR 1.05, 95% CI 0.67–1.65, p = .82) or DFS (HR 1.14, 95% CI 0.76–1.73, p = 0.52). ConclusionsTabled 1Overall survivalDisease free survivalMean sizeHR (95% CI)HR (95% CI)MdetCdetNon-black (NB)Mdet 0.53 (0.35–0.78)Mdet 0.68 (0.47–0.98)1.17 cm (All)1.83 cm (All)CMD 1.52 (1.02–2.27)CMD 1.44 (1.00–2.07)1.18 cm (NB)1.77 cm (NB)Inc. age 1.06 (1.04–1.08)Inc. age 1.04 (1.02–1.06)1.15 cm (B)1.85 cm (B)Inc. Wt 1.01 (1.00–1.02)p = 0.68p = .20Black (B)Inc. age 1.07 (1.03–1.07)Inc. age 1.05 (1.03–1.07) Open table in a new tab" @default.
• W2000430869 created "2016-06-24" @default.
• W2000430869 creator A5018304161 @default.
• W2000430869 creator A5044870790 @default.
• W2000430869 creator A5054855052 @default.
• W2000430869 creator A5055476105 @default.
• W2000430869 creator A5077701955 @default.
• W2000430869 creator A5085503714 @default.
• W2000430869 date "2007-11-01" @default.
• W2000430869 modified "2023-09-26" @default.
• W2000430869 title "The Impact of Race and Mammographic Detection in Early Breast Cancer" @default.
• W2000430869 doi "https://doi.org/10.1016/j.ijrobp.2007.07.1184" @default.
• W2000430869 hasPublicationYear "2007" @default.
• W2000430869 type Work @default.
• W2000430869 sameAs 2000430869 @default.
• W2000430869 citedByCount "0" @default.
• W2000430869 crossrefType "journal-article" @default.
• W2000430869 hasAuthorship W2000430869A5018304161 @default.
• W2000430869 hasAuthorship W2000430869A5044870790 @default.
• W2000430869 hasAuthorship W2000430869A5054855052 @default.
• W2000430869 hasAuthorship W2000430869A5055476105 @default.
• W2000430869 hasAuthorship W2000430869A5077701955 @default.
• W2000430869 hasAuthorship W2000430869A5085503714 @default.
• W2000430869 hasConcept C107993555 @default.
• W2000430869 hasConcept C121608353 @default.
• W2000430869 hasConcept C126322002 @default.
• W2000430869 hasConcept C143998085 @default.
• W2000430869 hasConcept C144024400 @default.
• W2000430869 hasConcept C2780472235 @default.
• W2000430869 hasConcept C29456083 @default.
• W2000430869 hasConcept C530470458 @default.
• W2000430869 hasConcept C71924100 @default.
• W2000430869 hasConcept C76509639 @default.
• W2000430869 hasConceptScore W2000430869C107993555 @default.
• W2000430869 hasConceptScore W2000430869C121608353 @default.
• W2000430869 hasConceptScore W2000430869C126322002 @default.
• W2000430869 hasConceptScore W2000430869C143998085 @default.
• W2000430869 hasConceptScore W2000430869C144024400 @default.
• W2000430869 hasConceptScore W2000430869C2780472235 @default.
• W2000430869 hasConceptScore W2000430869C29456083 @default.
• W2000430869 hasConceptScore W2000430869C530470458 @default.
• W2000430869 hasConceptScore W2000430869C71924100 @default.
• W2000430869 hasConceptScore W2000430869C76509639 @default.
• W2000430869 hasIssue "3" @default.
• W2000430869 hasLocation W20004308691 @default.
• W2000430869 hasOpenAccess W2000430869 @default.
• W2000430869 hasPrimaryLocation W20004308691 @default.
• W2000430869 hasRelatedWork W1971803455 @default.
• W2000430869 hasRelatedWork W1999344589 @default.
• W2000430869 hasRelatedWork W2020264843 @default.
• W2000430869 hasRelatedWork W2387047992 @default.
• W2000430869 hasRelatedWork W2411757190 @default.
• W2000430869 hasRelatedWork W2789448498 @default.
• W2000430869 hasRelatedWork W2806905600 @default.
• W2000430869 hasRelatedWork W377899687 @default.
• W2000430869 hasRelatedWork W4205830253 @default.
• W2000430869 hasRelatedWork W4309024054 @default.
• W2000430869 hasVolume "69" @default.
• W2000430869 isParatext "false" @default.
• W2000430869 isRetracted "false" @default.
• W2000430869 magId "2000430869" @default.
• W2000430869 workType "article" @default.