FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000431016> ?p ?o ?g. }

• W2000431016 endingPage "344" @default.
• W2000431016 startingPage "333" @default.
• W2000431016 abstract "Although there is a long history of exposure to allergy vaccines containing L-tyrosine, there has been no central publication reviewing its adjuvant properties in animal and human studies together with an assessment of its safe use. This paper summarizes a range of investigational data (unpublished) available to the authors as well as published literature reports. An array of in vitro and in vivo studies showed that L-tyrosine has ideal adjuvant properties, comprising a high adsorptive power for proteins, enhancement of IgG antibody induction with no stimulatory effect on IgE antibody level and action as a short-term depot adjuvant, delaying the bioavailability of allergenic materials rather than directly influencing immunocompetent cells. A series of preclinical safety investigations comprised single-dose parenteral studies in the mouse and rat, repeat-dose parenteral toxicity studies over 28 days in the rat and dog (up to 25 mg kg(-1) day(-1)) plus genotoxicity and local tolerance studies. No signs of toxicity or genotoxicity were seen; repeat-dose toxicity studies showed expected white cell and spleen weight immunostimulatory effects; local-dose site reactions were also seen and were confirmed in local tolerance studies. Findings from a range of clinical studies using allergy vaccines containing L-tyrosine reflected the lack of toxicity seen in animal work and showed evidence of enhanced immunostimulatory activity. Local injection site reactions (a common response to any form of clinical vaccination) in these studies were likely to be due to the presence of L-tyrosine per se. The lack of findings of toxicological concern found during this review supports the hypothesis that L-tyrosine is a safe adjuvant for human use." @default.
• W2000431016 created "2016-06-24" @default.
• W2000431016 creator A5038520165 @default.
• W2000431016 creator A5043791004 @default.
• W2000431016 creator A5091395134 @default.
• W2000431016 date "2002-01-01" @default.
• W2000431016 modified "2023-09-30" @default.
• W2000431016 title "Review ofL-tyrosine confirming its safe human use as an adjuvant" @default.
• W2000431016 cites W1572881837 @default.
• W2000431016 cites W1921669714 @default.
• W2000431016 cites W1964354442 @default.
• W2000431016 cites W1969498311 @default.
• W2000431016 cites W1969819023 @default.
• W2000431016 cites W1972300422 @default.
• W2000431016 cites W2002636234 @default.
• W2000431016 cites W2023307917 @default.
• W2000431016 cites W2043614266 @default.
• W2000431016 cites W2049218946 @default.
• W2000431016 cites W2066892212 @default.
• W2000431016 cites W2084995223 @default.
• W2000431016 cites W2105667065 @default.
• W2000431016 cites W2109910974 @default.
• W2000431016 cites W2115073614 @default.
• W2000431016 cites W2117243106 @default.
• W2000431016 cites W2140649712 @default.
• W2000431016 cites W2143270581 @default.
• W2000431016 cites W2154869757 @default.
• W2000431016 cites W2158722634 @default.
• W2000431016 cites W37179351 @default.
• W2000431016 cites W97562825 @default.
• W2000431016 doi "https://doi.org/10.1002/jat.869" @default.
• W2000431016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12355563" @default.
• W2000431016 hasPublicationYear "2002" @default.
• W2000431016 type Work @default.
• W2000431016 sameAs 2000431016 @default.
• W2000431016 citedByCount "57" @default.
• W2000431016 countsByYear W20004310162013 @default.
• W2000431016 countsByYear W20004310162014 @default.
• W2000431016 countsByYear W20004310162015 @default.
• W2000431016 countsByYear W20004310162016 @default.
• W2000431016 countsByYear W20004310162017 @default.
• W2000431016 countsByYear W20004310162018 @default.
• W2000431016 countsByYear W20004310162019 @default.
• W2000431016 countsByYear W20004310162020 @default.
• W2000431016 countsByYear W20004310162021 @default.
• W2000431016 countsByYear W20004310162022 @default.
• W2000431016 countsByYear W20004310162023 @default.
• W2000431016 crossrefType "journal-article" @default.
• W2000431016 hasAuthorship W2000431016A5038520165 @default.
• W2000431016 hasAuthorship W2000431016A5043791004 @default.
• W2000431016 hasAuthorship W2000431016A5091395134 @default.
• W2000431016 hasConcept C126322002 @default.
• W2000431016 hasConcept C150903083 @default.
• W2000431016 hasConcept C159654299 @default.
• W2000431016 hasConcept C181389837 @default.
• W2000431016 hasConcept C203014093 @default.
• W2000431016 hasConcept C207001950 @default.
• W2000431016 hasConcept C207480886 @default.
• W2000431016 hasConcept C2777863537 @default.
• W2000431016 hasConcept C2778959862 @default.
• W2000431016 hasConcept C2780931953 @default.
• W2000431016 hasConcept C29730261 @default.
• W2000431016 hasConcept C71924100 @default.
• W2000431016 hasConcept C86803240 @default.
• W2000431016 hasConcept C98274493 @default.
• W2000431016 hasConceptScore W2000431016C126322002 @default.
• W2000431016 hasConceptScore W2000431016C150903083 @default.
• W2000431016 hasConceptScore W2000431016C159654299 @default.
• W2000431016 hasConceptScore W2000431016C181389837 @default.
• W2000431016 hasConceptScore W2000431016C203014093 @default.
• W2000431016 hasConceptScore W2000431016C207001950 @default.
• W2000431016 hasConceptScore W2000431016C207480886 @default.
• W2000431016 hasConceptScore W2000431016C2777863537 @default.
• W2000431016 hasConceptScore W2000431016C2778959862 @default.
• W2000431016 hasConceptScore W2000431016C2780931953 @default.
• W2000431016 hasConceptScore W2000431016C29730261 @default.
• W2000431016 hasConceptScore W2000431016C71924100 @default.
• W2000431016 hasConceptScore W2000431016C86803240 @default.
• W2000431016 hasConceptScore W2000431016C98274493 @default.
• W2000431016 hasIssue "5" @default.
• W2000431016 hasLocation W20004310161 @default.
• W2000431016 hasLocation W20004310162 @default.
• W2000431016 hasOpenAccess W2000431016 @default.
• W2000431016 hasPrimaryLocation W20004310161 @default.
• W2000431016 hasRelatedWork W1965016416 @default.
• W2000431016 hasRelatedWork W1986962886 @default.
• W2000431016 hasRelatedWork W2079763637 @default.
• W2000431016 hasRelatedWork W2091355127 @default.
• W2000431016 hasRelatedWork W2332085314 @default.
• W2000431016 hasRelatedWork W2379311614 @default.
• W2000431016 hasRelatedWork W2604710955 @default.
• W2000431016 hasRelatedWork W2753834235 @default.
• W2000431016 hasRelatedWork W3006639556 @default.
• W2000431016 hasRelatedWork W3208312538 @default.
• W2000431016 hasVolume "22" @default.
• W2000431016 isParatext "false" @default.
• W2000431016 isRetracted "false" @default.
• W2000431016 magId "2000431016" @default.

• next