Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000432989> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2000432989 endingPage "3583" @default.
- W2000432989 startingPage "3577" @default.
- W2000432989 abstract "We reported earlier that occasional neurons evolve in human cultures of pluripotent ovarian epithelial stem cells. In subsequent experiments, frequent transdifferentiation into neural stem cells (NSC) and differentiating neurons was observed in human ovarian epithelial stem cells and porcine granulosa cells after exposure to certain combinations of sex steroids. Testosterone (TS), progesterone (PG) or estradiol (E2) alone do not increase the emergence of neurons. However, a mixture of TS+PG after E2 pretreatment converted a majority of ovarian epithelial stem cells or porcine granulosa cells into NSC and differentiating neuronal cells within one to three hours. Cultured neurons manifested an interconnectivity resembling primitive neuronal pathways in culture. These converted cells expressed the cell markers SSEA-1, SSEA-4, NCAM, and Thy-1 glycoconjugates of NSC and neurons, and differentiating cells showed characteristic neuronal morphology. Emergence of NSC and neuronal cells was associated with significant cellular depletion of L-glutamic acid (glutamate), which serves as the major excitatory neurotransmitter in the vertebrate CNS and its fast removal is essential for preventing glutamate excitotoxicity. These observations suggest that certain sequential systemic treatment with common sex steroids and their mixture might be effective in the treatment or prevention of degenerative CNS disorders. The ovarian stem cell cultures readily obtainable from human ovaries regardless of the woman's age have the potential to produce NSC for autologous regenerative treatment of neurologic diseases in aging women. Finally, the proper combination of sex steroids could possibly be employed for transdifferentiation of adult bone marrow stem cells or mobilized peripheral blood cells into autologous NSC and stimulate their neuronal differentiation after homing in the CNS." @default.
- W2000432989 created "2016-06-24" @default.
- W2000432989 creator A5021728410 @default.
- W2000432989 creator A5054918514 @default.
- W2000432989 creator A5088673821 @default.
- W2000432989 date "2008-11-15" @default.
- W2000432989 modified "2023-09-25" @default.
- W2000432989 title "Steroid-mediated differentiation of neural/neuronal cells from epithelial ovarian precursors in vitro" @default.
- W2000432989 doi "https://doi.org/10.4161/cc.7.22.7101" @default.
- W2000432989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19001872" @default.
- W2000432989 hasPublicationYear "2008" @default.
- W2000432989 type Work @default.
- W2000432989 sameAs 2000432989 @default.
- W2000432989 citedByCount "28" @default.
- W2000432989 countsByYear W20004329892012 @default.
- W2000432989 countsByYear W20004329892013 @default.
- W2000432989 countsByYear W20004329892014 @default.
- W2000432989 countsByYear W20004329892015 @default.
- W2000432989 countsByYear W20004329892016 @default.
- W2000432989 countsByYear W20004329892018 @default.
- W2000432989 countsByYear W20004329892019 @default.
- W2000432989 countsByYear W20004329892021 @default.
- W2000432989 countsByYear W20004329892022 @default.
- W2000432989 crossrefType "journal-article" @default.
- W2000432989 hasAuthorship W2000432989A5021728410 @default.
- W2000432989 hasAuthorship W2000432989A5054918514 @default.
- W2000432989 hasAuthorship W2000432989A5088673821 @default.
- W2000432989 hasConcept C104317684 @default.
- W2000432989 hasConcept C107459253 @default.
- W2000432989 hasConcept C134018914 @default.
- W2000432989 hasConcept C136834591 @default.
- W2000432989 hasConcept C138851942 @default.
- W2000432989 hasConcept C145103041 @default.
- W2000432989 hasConcept C148738053 @default.
- W2000432989 hasConcept C170493617 @default.
- W2000432989 hasConcept C20875687 @default.
- W2000432989 hasConcept C28328180 @default.
- W2000432989 hasConcept C55493867 @default.
- W2000432989 hasConcept C60870556 @default.
- W2000432989 hasConcept C61174792 @default.
- W2000432989 hasConcept C86803240 @default.
- W2000432989 hasConcept C95444343 @default.
- W2000432989 hasConceptScore W2000432989C104317684 @default.
- W2000432989 hasConceptScore W2000432989C107459253 @default.
- W2000432989 hasConceptScore W2000432989C134018914 @default.
- W2000432989 hasConceptScore W2000432989C136834591 @default.
- W2000432989 hasConceptScore W2000432989C138851942 @default.
- W2000432989 hasConceptScore W2000432989C145103041 @default.
- W2000432989 hasConceptScore W2000432989C148738053 @default.
- W2000432989 hasConceptScore W2000432989C170493617 @default.
- W2000432989 hasConceptScore W2000432989C20875687 @default.
- W2000432989 hasConceptScore W2000432989C28328180 @default.
- W2000432989 hasConceptScore W2000432989C55493867 @default.
- W2000432989 hasConceptScore W2000432989C60870556 @default.
- W2000432989 hasConceptScore W2000432989C61174792 @default.
- W2000432989 hasConceptScore W2000432989C86803240 @default.
- W2000432989 hasConceptScore W2000432989C95444343 @default.
- W2000432989 hasIssue "22" @default.
- W2000432989 hasLocation W20004329891 @default.
- W2000432989 hasLocation W20004329892 @default.
- W2000432989 hasOpenAccess W2000432989 @default.
- W2000432989 hasPrimaryLocation W20004329891 @default.
- W2000432989 hasRelatedWork W122409776 @default.
- W2000432989 hasRelatedWork W2009519731 @default.
- W2000432989 hasRelatedWork W2014593984 @default.
- W2000432989 hasRelatedWork W2028653430 @default.
- W2000432989 hasRelatedWork W2036904838 @default.
- W2000432989 hasRelatedWork W2086108024 @default.
- W2000432989 hasRelatedWork W2094081082 @default.
- W2000432989 hasRelatedWork W4226476957 @default.
- W2000432989 hasRelatedWork W4224937910 @default.
- W2000432989 hasRelatedWork W4228999338 @default.
- W2000432989 hasVolume "7" @default.
- W2000432989 isParatext "false" @default.
- W2000432989 isRetracted "false" @default.
- W2000432989 magId "2000432989" @default.
- W2000432989 workType "article" @default.