Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000433357> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2000433357 endingPage "106" @default.
- W2000433357 startingPage "106" @default.
- W2000433357 abstract "Five derivatives of menadione (2-methyl-1,4-naphthoquinone) having electronegative substituents on allylic carbons were prepared for study as sulfhydryl-reactive inactivators of mouse liver microsomal NADPH-cytochrome c reductase. Each of these naphthoquinones, incubated with dilute suspensions of microsomes, produced a loss of NADPH-cytochrome c reductase activity proportional to the initial naphthoquinone concentration. Each of the compounds also reacted with cysteine, as evidenced in the case of the haloggated compounds, by loss of reactive sulfhydryl groups and, in the case of 2-p-nitrophenoxymenadione, by the displacement of the leaving group, p-nitrophenol. Menadione, incubated under identical conditions, did not inactivate NADPH-cytochrome c reductase and was unreactive with cysteine. The requirement for a halogen or a nitrophenoxy substituent on at least one of the allylic carbons suggested that the mechanism of NADPH-cytochrome c reductase inactivation involves attack on critical microsomal nucleophiles, possibly sulhydryl groups. The possible significance of these findings is discussed in relation to the antitumor activity and bioactivation of the halomethyl naphthoquinones." @default.
- W2000433357 created "2016-06-24" @default.
- W2000433357 creator A5003944475 @default.
- W2000433357 creator A5010967300 @default.
- W2000433357 creator A5090562007 @default.
- W2000433357 date "1991-02-01" @default.
- W2000433357 modified "2023-09-27" @default.
- W2000433357 title "Induction of chromosomal aberrations in active oxygen-generating systems. VII. Isolation of menadione-resistant subclones from mutagenized Chinese hamster cells" @default.
- W2000433357 doi "https://doi.org/10.1016/0165-1161(91)90310-5" @default.
- W2000433357 hasPublicationYear "1991" @default.
- W2000433357 type Work @default.
- W2000433357 sameAs 2000433357 @default.
- W2000433357 citedByCount "0" @default.
- W2000433357 crossrefType "journal-article" @default.
- W2000433357 hasAuthorship W2000433357A5003944475 @default.
- W2000433357 hasAuthorship W2000433357A5010967300 @default.
- W2000433357 hasAuthorship W2000433357A5090562007 @default.
- W2000433357 hasConcept C114246631 @default.
- W2000433357 hasConcept C134651460 @default.
- W2000433357 hasConcept C153911025 @default.
- W2000433357 hasConcept C181199279 @default.
- W2000433357 hasConcept C185592680 @default.
- W2000433357 hasConcept C2776639595 @default.
- W2000433357 hasConcept C2777755551 @default.
- W2000433357 hasConcept C2778575167 @default.
- W2000433357 hasConcept C2779201268 @default.
- W2000433357 hasConcept C2780768313 @default.
- W2000433357 hasConcept C2781095387 @default.
- W2000433357 hasConcept C552990157 @default.
- W2000433357 hasConcept C55493867 @default.
- W2000433357 hasConcept C71240020 @default.
- W2000433357 hasConcept C86803240 @default.
- W2000433357 hasConcept C87644729 @default.
- W2000433357 hasConceptScore W2000433357C114246631 @default.
- W2000433357 hasConceptScore W2000433357C134651460 @default.
- W2000433357 hasConceptScore W2000433357C153911025 @default.
- W2000433357 hasConceptScore W2000433357C181199279 @default.
- W2000433357 hasConceptScore W2000433357C185592680 @default.
- W2000433357 hasConceptScore W2000433357C2776639595 @default.
- W2000433357 hasConceptScore W2000433357C2777755551 @default.
- W2000433357 hasConceptScore W2000433357C2778575167 @default.
- W2000433357 hasConceptScore W2000433357C2779201268 @default.
- W2000433357 hasConceptScore W2000433357C2780768313 @default.
- W2000433357 hasConceptScore W2000433357C2781095387 @default.
- W2000433357 hasConceptScore W2000433357C552990157 @default.
- W2000433357 hasConceptScore W2000433357C55493867 @default.
- W2000433357 hasConceptScore W2000433357C71240020 @default.
- W2000433357 hasConceptScore W2000433357C86803240 @default.
- W2000433357 hasConceptScore W2000433357C87644729 @default.
- W2000433357 hasIssue "1" @default.
- W2000433357 hasLocation W20004333571 @default.
- W2000433357 hasOpenAccess W2000433357 @default.
- W2000433357 hasPrimaryLocation W20004333571 @default.
- W2000433357 hasRelatedWork W1526702851 @default.
- W2000433357 hasRelatedWork W1798833167 @default.
- W2000433357 hasRelatedWork W1964130393 @default.
- W2000433357 hasRelatedWork W2002195201 @default.
- W2000433357 hasRelatedWork W2048301628 @default.
- W2000433357 hasRelatedWork W2162305712 @default.
- W2000433357 hasRelatedWork W2166420775 @default.
- W2000433357 hasRelatedWork W2236512361 @default.
- W2000433357 hasRelatedWork W225255128 @default.
- W2000433357 hasRelatedWork W4250393268 @default.
- W2000433357 hasVolume "252" @default.
- W2000433357 isParatext "false" @default.
- W2000433357 isRetracted "false" @default.
- W2000433357 magId "2000433357" @default.
- W2000433357 workType "article" @default.