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• W2000435086 abstract "Abstract Evidence supports a pathogenic role for free radical injury to brain in Alzheimer's disease; however, clinical trial results are only mildly encouraging. Examining brains from The Adult Changes in Thought study offers a unique perspective. Selectively increased free radical damage to cerebral cortex was associated with Alzheimer's disease, microvascular brain injury, and current smoking, but not with antioxidant supplement usage. Our results support suppression of free radical injury to brain as a therapeutic target for Alzheimer's disease and microvascular brain injury; however, future clinical trials should consider other antioxidants or doses than those identified in our study. Ann Neurol 2009;65:226–229" @default.
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• W2000435086 date "2009-02-01" @default.
• W2000435086 modified "2023-10-17" @default.
• W2000435086 title "Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking" @default.
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• W2000435086 doi "https://doi.org/10.1002/ana.21508" @default.
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