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• W2000435348 abstract "Presbycusis is a progressive hearing loss related to the aging process associated with auditory receptor degeneration. Adult animals exhibited galectine-1 (GAL-1) expression in epithelial cells of the inner and outer spiral sulci and Hensen cells, which was absent from the sensory and supporting cells. The progressive age-related degeneration of auditory receptor was analyzed using an anti-GAL-1 monoclonal antibody on cochleae of C57BL/6 mice (1-24 months old). Mice < or = 9 months old showed adult and healthy auditory receptors, with a similar GAL-1 expression along the time. Conversely, animals > 1 year old exhibited a sensory degeneration at the cochleae basal coil that progressively reached the middle coil. Older animals (18-24 months old) showed a single layer epithelium that replaced the auditory receptor. The age-related degenerative process of the auditory receptor involves sensory but also supporting cells, which are both substituted by epithelial non-specialized cells." @default.
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• W2000435348 date "2001-10-01" @default.
• W2000435348 modified "2023-10-01" @default.
• W2000435348 title "Galectine-1 expression in cochleae of C57BL/6 mice during aging" @default.
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• W2000435348 doi "https://doi.org/10.1097/00001756-200110080-00025" @default.
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