FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000436863> ?p ?o ?g. }

• W2000436863 endingPage "151" @default.
• W2000436863 startingPage "140" @default.
• W2000436863 abstract "c-Jun N-terminal protein kinase (JNK) is a member of the mitogen-activated protein kinase (MAPK) superfamily. The activation of JNK is mediated by sequential protein phosphorylation through a MAPK module, namely, MAPK kinase kinase (MAP3K or MEKK) → MAPK kinase (MAP2K or MKK) → MAPK. Elevated levels of JNK activity have been frequently observed in hepatocellular carcinoma (HCC) and have been demonstrated to contribute to HCC growth by promoting HCC cell proliferation and resistance to tumor necrosis factor–related apoptosis-inducing ligand (TRAIL)- or Fas-mediated apoptosis. Chronic inflammation contributes to the up-regulation of JNK activity in HCC. However, it remains unknown whether aberrant JNK activity also results from some cell intrinsic defect(s). Here, we show that receptor for activated C kinase 1 (RACK1), an adaptor protein implicated in the regulation of multiple signaling pathways, could engage in a direct interaction with MKK7, the JNK-specific MAP2K, in human HCC cells. Levels of RACK1 protein show correlation with the activity of the JNK pathway in human HCC tissues and cell lines. RACK1 loss-of-function or gain-of-function analyses indicate that RACK1 enhances MKK7/JNK activity in human HCC cells. Further exploration reveals that the interaction of RACK1 with MKK7 is required for the enhancement of MKK7/JNK activity by RACK1. RACK1/MKK7 interaction facilitates the association of MKK7 with MAP3Ks, thereby enhancing MKK7 activity and promoting in vitro HCC cell proliferation and resistance to TRAIL- or Fas-mediated apoptosis as well as in vivo tumor growth. Conclusion: Overexpressed RACK1 augments JNK activity and thereby promotes HCC growth through directly binding to MKK7 and enhancing MKK7 activity. (HEPATOLOGY 2013)" @default.
• W2000436863 created "2016-06-24" @default.
• W2000436863 creator A5005005012 @default.
• W2000436863 creator A5013205564 @default.
• W2000436863 creator A5022857808 @default.
• W2000436863 creator A5025924031 @default.
• W2000436863 creator A5037677450 @default.
• W2000436863 creator A5042351991 @default.
• W2000436863 creator A5043717687 @default.
• W2000436863 creator A5049035866 @default.
• W2000436863 creator A5060514130 @default.
• W2000436863 creator A5062537067 @default.
• W2000436863 creator A5074949196 @default.
• W2000436863 creator A5086780566 @default.
• W2000436863 date "2013-01-01" @default.
• W2000436863 modified "2023-10-16" @default.
• W2000436863 title "Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity" @default.
• W2000436863 cites W1565491355 @default.
• W2000436863 cites W1983687466 @default.
• W2000436863 cites W1990239056 @default.
• W2000436863 cites W1994170326 @default.
• W2000436863 cites W2018460745 @default.
• W2000436863 cites W2019953132 @default.
• W2000436863 cites W2022802363 @default.
• W2000436863 cites W2031962092 @default.
• W2000436863 cites W2039674021 @default.
• W2000436863 cites W2047514293 @default.
• W2000436863 cites W2048831823 @default.
• W2000436863 cites W2076515532 @default.
• W2000436863 cites W2116189372 @default.
• W2000436863 cites W2116254970 @default.
• W2000436863 cites W2118714054 @default.
• W2000436863 cites W2126022174 @default.
• W2000436863 cites W2128817499 @default.
• W2000436863 cites W2134303676 @default.
• W2000436863 cites W2134719648 @default.
• W2000436863 cites W2136701323 @default.
• W2000436863 cites W2148255564 @default.
• W2000436863 cites W2149136061 @default.
• W2000436863 cites W2168242281 @default.
• W2000436863 cites W4243625103 @default.
• W2000436863 doi "https://doi.org/10.1002/hep.25978" @default.
• W2000436863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22903704" @default.
• W2000436863 hasPublicationYear "2013" @default.
• W2000436863 type Work @default.
• W2000436863 sameAs 2000436863 @default.
• W2000436863 citedByCount "56" @default.
• W2000436863 countsByYear W20004368632013 @default.
• W2000436863 countsByYear W20004368632014 @default.
• W2000436863 countsByYear W20004368632015 @default.
• W2000436863 countsByYear W20004368632016 @default.
• W2000436863 countsByYear W20004368632017 @default.
• W2000436863 countsByYear W20004368632018 @default.
• W2000436863 countsByYear W20004368632019 @default.
• W2000436863 countsByYear W20004368632020 @default.
• W2000436863 countsByYear W20004368632021 @default.
• W2000436863 countsByYear W20004368632022 @default.
• W2000436863 crossrefType "journal-article" @default.
• W2000436863 hasAuthorship W2000436863A5005005012 @default.
• W2000436863 hasAuthorship W2000436863A5013205564 @default.
• W2000436863 hasAuthorship W2000436863A5022857808 @default.
• W2000436863 hasAuthorship W2000436863A5025924031 @default.
• W2000436863 hasAuthorship W2000436863A5037677450 @default.
• W2000436863 hasAuthorship W2000436863A5042351991 @default.
• W2000436863 hasAuthorship W2000436863A5043717687 @default.
• W2000436863 hasAuthorship W2000436863A5049035866 @default.
• W2000436863 hasAuthorship W2000436863A5060514130 @default.
• W2000436863 hasAuthorship W2000436863A5062537067 @default.
• W2000436863 hasAuthorship W2000436863A5074949196 @default.
• W2000436863 hasAuthorship W2000436863A5086780566 @default.
• W2000436863 hasBestOaLocation W20004368631 @default.
• W2000436863 hasConcept C124160383 @default.
• W2000436863 hasConcept C132149769 @default.
• W2000436863 hasConcept C137361374 @default.
• W2000436863 hasConcept C159479382 @default.
• W2000436863 hasConcept C161238802 @default.
• W2000436863 hasConcept C184235292 @default.
• W2000436863 hasConcept C185592680 @default.
• W2000436863 hasConcept C502942594 @default.
• W2000436863 hasConcept C57074206 @default.
• W2000436863 hasConcept C59143045 @default.
• W2000436863 hasConcept C82495950 @default.
• W2000436863 hasConcept C86803240 @default.
• W2000436863 hasConcept C90934575 @default.
• W2000436863 hasConcept C95444343 @default.
• W2000436863 hasConcept C97029542 @default.
• W2000436863 hasConceptScore W2000436863C124160383 @default.
• W2000436863 hasConceptScore W2000436863C132149769 @default.
• W2000436863 hasConceptScore W2000436863C137361374 @default.
• W2000436863 hasConceptScore W2000436863C159479382 @default.
• W2000436863 hasConceptScore W2000436863C161238802 @default.
• W2000436863 hasConceptScore W2000436863C184235292 @default.
• W2000436863 hasConceptScore W2000436863C185592680 @default.
• W2000436863 hasConceptScore W2000436863C502942594 @default.
• W2000436863 hasConceptScore W2000436863C57074206 @default.
• W2000436863 hasConceptScore W2000436863C59143045 @default.
• W2000436863 hasConceptScore W2000436863C82495950 @default.
• W2000436863 hasConceptScore W2000436863C86803240 @default.

• next