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- W2000437622 abstract "Somatuline, in common with other SRIH analogues, exerts antiproliferative and antisecretory activities on various tumors. Our purpose was to test the effectiveness of a slow-release formulation of somatuline on lactotroph hyperplasia and PRL hypersecretion induced by estrogens (17 βE2) in rats. Female rats were primed with 17 βE2 for 6 weeks before receiving somatuline (2 mg/kg) intramuscular injections every 10 days for one month. The mean anterior pituitary weight was 11.22 ± 0.32 mg (mean ± SEM) in non-estrogenized rats, 29.62 ± 1.63 mg in 17 βE2-primed rats and 23.58 ± 1.26 mg in 17 βE2-primed somatuline-treated rats. Mean plasma PRL level was 5.63 ± 0.97 ng/ml, 182.37 ± 27.55 ng/ml and 113.89 ± 15.07 ng/ml in the same groups respectively. Thus, the 17 βE2-induced pituitary enlargement and hyperprolactinemia were 20% and 38% lower respectively when animals were treated with somatuline during the last month of estrogenization. The 17 βE2-induced increase in PRL cell density was also reduced by somatuline treatment. We conclude that the slow-release formulation of somatuline impedes 17 βE2-induced hyperprolactinemia and pituitary enlargement concomittantly, at least in part by acting on lactotroph proliferation." @default.
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- W2000437622 date "1994-06-01" @default.
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- W2000437622 title "Effect of the slow-release formulation of somatuline (BIM 23014) on estrogen-induced hyperprolactinemia and lactotroph hyperplasia in the female rat" @default.
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- W2000437622 doi "https://doi.org/10.1016/0143-4179(94)90025-6" @default.
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