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• W2000438098 abstract "In vitro salicylates/aspirin, salicylic acid, salicylamide and gentisic acid/inhibited formation of 12-lipoxygenase products in intact human washed platelets which were stimulated with thrombin or arachidonic acid. Salicylates did not affect 12-lipoxygenase activity in platelet lysates. Ex vivo aspirin or salicylamide at a dose of 1 g given orally to healthy volunteers potentiated formation of 12-lipoxygenase products in washed platelets. It is concluded that the effect of salicylates on 12-lipoxygenase pathway is independent from their influence on cyclooxygenase activity in platelets and aspirin cannot be considered as a selective inhibitor of platelet cyclooxygenase." @default.
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• W2000438098 date "1986-11-01" @default.
• W2000438098 modified "2023-09-27" @default.
• W2000438098 title "Salicylates and 12-lipoxygenase activity in human washed platelets" @default.
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• W2000438098 doi "https://doi.org/10.1016/0031-6989(86)90019-6" @default.
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