Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000439631> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2000439631 abstract "We investigated the power of the affected sibpair method for detecting a disease locus when the disease is inherited through two bi-allelic loci. The power was computed for all possible values of the gene frequencies and penetrances that lead to a given population prevalence and a given sibling relative risk. A method to generate rapidly all possible models that give a specific population prevalence and relative risk is provided. We applied it to the case of a two-locus disease with a prevalence of 10% and a low sibling relative risk of 1.5. For this particular example, regardless of the true underlying model, a sample size (N = 450 for alpha = 0.05, N = 1,500 for alpha = 0.0001) may be determined such that one would expect enough power (0.80) to detect at least one of the two disease genes. In addition to the general case, we examined a special class of models in which the marginal penetrances at each locus are either recessive or dominant. In this instance, the gene frequencies were excellent predictors of the power afforded by a particular sample size. These methods have been implemented in a C program called SIBPOWER which is freely available from the first author. With this program, investigators can perform their own power calculations for any two-locus model of their choice thus avoiding the need to use single-locus approximations that may grossly underestimate the necessary sample size." @default.
- W2000439631 created "2016-06-24" @default.
- W2000439631 creator A5006843547 @default.
- W2000439631 creator A5023169260 @default.
- W2000439631 creator A5027220505 @default.
- W2000439631 date "1997-01-01" @default.
- W2000439631 modified "2023-09-26" @default.
- W2000439631 title "Linkage analysis of complex traits using affected sibpairs: Effects of single-locus approximations on estimates of the required sample size" @default.
- W2000439631 cites W1488318879 @default.
- W2000439631 cites W1598231852 @default.
- W2000439631 cites W1905577439 @default.
- W2000439631 cites W1976741643 @default.
- W2000439631 cites W2020478378 @default.
- W2000439631 cites W2113716249 @default.
- W2000439631 cites W2122389871 @default.
- W2000439631 cites W2123869079 @default.
- W2000439631 cites W2124910053 @default.
- W2000439631 doi "https://doi.org/10.1002/(sici)1098-2272(1997)14:4<389::aid-gepi4>3.0.co;2-z" @default.
- W2000439631 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9271711" @default.
- W2000439631 hasPublicationYear "1997" @default.
- W2000439631 type Work @default.
- W2000439631 sameAs 2000439631 @default.
- W2000439631 citedByCount "7" @default.
- W2000439631 countsByYear W20004396312014 @default.
- W2000439631 crossrefType "journal-article" @default.
- W2000439631 hasAuthorship W2000439631A5006843547 @default.
- W2000439631 hasAuthorship W2000439631A5023169260 @default.
- W2000439631 hasAuthorship W2000439631A5027220505 @default.
- W2000439631 hasConcept C104317684 @default.
- W2000439631 hasConcept C105795698 @default.
- W2000439631 hasConcept C129848803 @default.
- W2000439631 hasConcept C138496976 @default.
- W2000439631 hasConcept C144024400 @default.
- W2000439631 hasConcept C149782125 @default.
- W2000439631 hasConcept C149923435 @default.
- W2000439631 hasConcept C15744967 @default.
- W2000439631 hasConcept C180754005 @default.
- W2000439631 hasConcept C2776194465 @default.
- W2000439631 hasConcept C2908647359 @default.
- W2000439631 hasConcept C33923547 @default.
- W2000439631 hasConcept C54355233 @default.
- W2000439631 hasConcept C84597430 @default.
- W2000439631 hasConcept C86803240 @default.
- W2000439631 hasConceptScore W2000439631C104317684 @default.
- W2000439631 hasConceptScore W2000439631C105795698 @default.
- W2000439631 hasConceptScore W2000439631C129848803 @default.
- W2000439631 hasConceptScore W2000439631C138496976 @default.
- W2000439631 hasConceptScore W2000439631C144024400 @default.
- W2000439631 hasConceptScore W2000439631C149782125 @default.
- W2000439631 hasConceptScore W2000439631C149923435 @default.
- W2000439631 hasConceptScore W2000439631C15744967 @default.
- W2000439631 hasConceptScore W2000439631C180754005 @default.
- W2000439631 hasConceptScore W2000439631C2776194465 @default.
- W2000439631 hasConceptScore W2000439631C2908647359 @default.
- W2000439631 hasConceptScore W2000439631C33923547 @default.
- W2000439631 hasConceptScore W2000439631C54355233 @default.
- W2000439631 hasConceptScore W2000439631C84597430 @default.
- W2000439631 hasConceptScore W2000439631C86803240 @default.
- W2000439631 hasLocation W20004396311 @default.
- W2000439631 hasLocation W20004396312 @default.
- W2000439631 hasOpenAccess W2000439631 @default.
- W2000439631 hasPrimaryLocation W20004396311 @default.
- W2000439631 hasRelatedWork W1965394388 @default.
- W2000439631 hasRelatedWork W1972858993 @default.
- W2000439631 hasRelatedWork W2003264273 @default.
- W2000439631 hasRelatedWork W2017189173 @default.
- W2000439631 hasRelatedWork W2025970721 @default.
- W2000439631 hasRelatedWork W2057739827 @default.
- W2000439631 hasRelatedWork W2134565701 @default.
- W2000439631 hasRelatedWork W2143408077 @default.
- W2000439631 hasRelatedWork W2153030702 @default.
- W2000439631 hasRelatedWork W2166717297 @default.
- W2000439631 isParatext "false" @default.
- W2000439631 isRetracted "false" @default.
- W2000439631 magId "2000439631" @default.
- W2000439631 workType "article" @default.