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- W2000439830 abstract "The alcohol dehydgrogenases in yeast form one of the best-understood eukaryotic regulatory systems at the genetic level, but very little is known about their regulation at the biochemical level. We report on a simple whole-cell assay system for the induction of the inducible isozyme, alcohol dehydrogenase II, which has been used to show that no single compound added to the medium is responsible for the induction. The compounds which show the greatest inducing activity — malate, glutamate and fumarate — are all directly or indirectly involved in mitochondrial transport systems. No single compound can be purified from extracts of yeast cells to give inducing activity at low concentrations, suggesting that the inducing activity is an endogenous function of the cell. Tentative models for regulation of this isozyme involving the mitochondrion are proposed, and suggestions are made for testing these models further." @default.
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- W2000439830 date "1984-07-01" @default.
- W2000439830 modified "2023-10-14" @default.
- W2000439830 title "Extracellular conditions affecting the induction of yeast alcohol dehydrogenase II" @default.
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- W2000439830 doi "https://doi.org/10.1016/0167-4781(84)90063-0" @default.
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