FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000440048> ?p ?o ?g. }

• W2000440048 endingPage "9" @default.
• W2000440048 startingPage "53" @default.
• W2000440048 abstract "The establishment of HCV replicon systems strongly improved the research on the replication processes but poorly advanced our knowledge on the subcellular localization of the structural glycoproteins, mainly due to their low expression. We sought to verify whether reinforcing E1E2 expression in the context of both HCV genomic and subgenomic replicon from either homologous or heterologous strains leads to formation of supramolecular structures including structural and nonstructural proteins.Robust expression of HCV glycoproteins was achieved by stable expression of E1E2p7 from genotype 1a and 1b.In these cells, E1 and E2 triggered the formation of dot-like structures in which they co-localized with core and the nonstructural proteins NS3 and NS5A. Confocal microscopy analyses suggested that accumulation of HCV proteins occurs in an ER-derived subcompartment. Moreover, by labeling de novo-synthesized HCV RNA, we showed that these structures constitute a site of viral RNA synthesis.Expression in trans of HCV glycoproteins in the context of replicative viral genome or subgenome generates accumulation of structural and nonstructural viral proteins in peculiar cytoplasmic structures. The simultaneous presence of viral RNA, structural and nonstructural protein suggests that these complexes represent not only sites of HCV replication but also potential places of viral pre-budding." @default.
• W2000440048 created "2016-06-24" @default.
• W2000440048 creator A5019283717 @default.
• W2000440048 creator A5024618440 @default.
• W2000440048 creator A5036094763 @default.
• W2000440048 creator A5043109657 @default.
• W2000440048 creator A5048416724 @default.
• W2000440048 creator A5065088326 @default.
• W2000440048 creator A5068670948 @default.
• W2000440048 creator A5076558532 @default.
• W2000440048 date "2007-01-01" @default.
• W2000440048 modified "2023-09-26" @default.
• W2000440048 title "Intracellular accumulation of hepatitis C virus proteins in a human hepatoma cell line." @default.
• W2000440048 cites W1530951444 @default.
• W2000440048 cites W1566969252 @default.
• W2000440048 cites W1964468772 @default.
• W2000440048 cites W1987002413 @default.
• W2000440048 cites W1987984630 @default.
• W2000440048 cites W2002857052 @default.
• W2000440048 cites W2018364492 @default.
• W2000440048 cites W2023645777 @default.
• W2000440048 cites W2044193462 @default.
• W2000440048 cites W2078770660 @default.
• W2000440048 cites W2078887917 @default.
• W2000440048 cites W2089167315 @default.
• W2000440048 cites W2090825777 @default.
• W2000440048 cites W2103598791 @default.
• W2000440048 cites W2104356883 @default.
• W2000440048 cites W2107085672 @default.
• W2000440048 cites W2110671968 @default.
• W2000440048 cites W2112930049 @default.
• W2000440048 cites W2127444976 @default.
• W2000440048 cites W2132341678 @default.
• W2000440048 cites W2132444008 @default.
• W2000440048 cites W2136523601 @default.
• W2000440048 cites W2137374406 @default.
• W2000440048 cites W2147126871 @default.
• W2000440048 cites W2150983148 @default.
• W2000440048 cites W2151898297 @default.
• W2000440048 cites W2154853638 @default.
• W2000440048 cites W2163868178 @default.
• W2000440048 doi "https://doi.org/10.1016/j.jhep.2006.09.009" @default.
• W2000440048 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17107733" @default.
• W2000440048 hasPublicationYear "2007" @default.
• W2000440048 type Work @default.
• W2000440048 sameAs 2000440048 @default.
• W2000440048 citedByCount "6" @default.
• W2000440048 countsByYear W20004400482012 @default.
• W2000440048 crossrefType "journal-article" @default.
• W2000440048 hasAuthorship W2000440048A5019283717 @default.
• W2000440048 hasAuthorship W2000440048A5024618440 @default.
• W2000440048 hasAuthorship W2000440048A5036094763 @default.
• W2000440048 hasAuthorship W2000440048A5043109657 @default.
• W2000440048 hasAuthorship W2000440048A5048416724 @default.
• W2000440048 hasAuthorship W2000440048A5065088326 @default.
• W2000440048 hasAuthorship W2000440048A5068670948 @default.
• W2000440048 hasAuthorship W2000440048A5076558532 @default.
• W2000440048 hasConcept C104317684 @default.
• W2000440048 hasConcept C10852380 @default.
• W2000440048 hasConcept C108625454 @default.
• W2000440048 hasConcept C132379496 @default.
• W2000440048 hasConcept C140704245 @default.
• W2000440048 hasConcept C141231307 @default.
• W2000440048 hasConcept C151730666 @default.
• W2000440048 hasConcept C153911025 @default.
• W2000440048 hasConcept C159047783 @default.
• W2000440048 hasConcept C18103114 @default.
• W2000440048 hasConcept C189819185 @default.
• W2000440048 hasConcept C202878990 @default.
• W2000440048 hasConcept C2522874641 @default.
• W2000440048 hasConcept C2776408679 @default.
• W2000440048 hasConcept C2777103181 @default.
• W2000440048 hasConcept C2779174946 @default.
• W2000440048 hasConcept C2779343474 @default.
• W2000440048 hasConcept C2780879997 @default.
• W2000440048 hasConcept C2781463415 @default.
• W2000440048 hasConcept C54355233 @default.
• W2000440048 hasConcept C58475186 @default.
• W2000440048 hasConcept C67705224 @default.
• W2000440048 hasConcept C86803240 @default.
• W2000440048 hasConcept C95444343 @default.
• W2000440048 hasConceptScore W2000440048C104317684 @default.
• W2000440048 hasConceptScore W2000440048C10852380 @default.
• W2000440048 hasConceptScore W2000440048C108625454 @default.
• W2000440048 hasConceptScore W2000440048C132379496 @default.
• W2000440048 hasConceptScore W2000440048C140704245 @default.
• W2000440048 hasConceptScore W2000440048C141231307 @default.
• W2000440048 hasConceptScore W2000440048C151730666 @default.
• W2000440048 hasConceptScore W2000440048C153911025 @default.
• W2000440048 hasConceptScore W2000440048C159047783 @default.
• W2000440048 hasConceptScore W2000440048C18103114 @default.
• W2000440048 hasConceptScore W2000440048C189819185 @default.
• W2000440048 hasConceptScore W2000440048C202878990 @default.
• W2000440048 hasConceptScore W2000440048C2522874641 @default.
• W2000440048 hasConceptScore W2000440048C2776408679 @default.
• W2000440048 hasConceptScore W2000440048C2777103181 @default.
• W2000440048 hasConceptScore W2000440048C2779174946 @default.
• W2000440048 hasConceptScore W2000440048C2779343474 @default.

• next