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- W2000440060 abstract "Abstract The effects of doxapram on the hepatic microsomal mono-oxygenase system of male and female rats were investigated. Male and female rats were administered doxapram (10–120 mg kg−1 day−1, i.p.) for 4 days. In female rats, administration of doxapram (20, 40, 60, 80, 100 and 120 mg kg−1) elevated the parameters in a dose-dependent manner while doxapram (100 and 120 mg kg−1) elevated the levels of cytochrome P450 and hexobarbitone hydroxylase in male rats. Doxapram (40 mg kg−1) caused induction of hepatic drug metabolism typified by an increase of hepatic microsomal cytochrome P450 content and activities of hexobarbitone hydroxylase, benzphetamine N-demethylase and ethylmorphine N-demethylase in female rats, but no change in male rats. These findings were supported by the results of SDS/polyacrylamide-gel electrophoresis. However, 7-ethoxycoumarin O-de-ethylase and arylhydrocarbon hydroxylase activities were significantly increased in male rats. NADPH-cytochrome c reductase and NADH-cytochrome c reductase activities, and cytochrome b5 content were unaffected in rats of both sexes. The sex-dependent cytochrome P450 species may be selectively sensitive to the action of doxapram." @default.
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- W2000440060 date "1993-11-01" @default.
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- W2000440060 title "Sex-related Differences in Rat Liver Microsomal Enzymes and Their Induction by Doxapram" @default.
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- W2000440060 doi "https://doi.org/10.1111/j.2042-7158.1993.tb05639.x" @default.
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