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• W2000440143 startingPage "243" @default.
• W2000440143 abstract "Bacillus subtilis, a spore-forming soil bacterium, is the preeminent model system for the analysis of gene regulation in Gram-positive bacteria. Early genetic analyses established that this organism uses alternative sigma (sigma) subunits to reprogram RNA polymerase to activate genes required for growth phase transitions, motility, general stress response, and sporulation. Unexpectedly, the genome sequence predicts the presence of an additional seven a subunits: all members of the extracytoplasmic function (ECF) a subfamily of regulators that typically respond to cell envelope stresses. Here, we review our current understanding of one of these a factors, sigmaW, with an emphasis on experimental strategies and approaches. Exposure to cell envelope active antibiotics and toxic peptides triggers a signaling cascade that releases sigmaW from its cognate anti-sigma thereby allowing transcription of approximately 60 sigmaW-dependent genes. These genes encode proteins that inactivate, sequester, or eliminate toxic compounds from the cell." @default.
• W2000440143 created "2016-06-24" @default.
• W2000440143 creator A5029976904 @default.
• W2000440143 date "2006-08-01" @default.
• W2000440143 modified "2023-10-03" @default.
• W2000440143 title "Deciphering a Complex Genetic Regulatory Network: The Bacillus Subtilis σ^W Protein and Intrinsic Resistance to Antimicrobial Compounds" @default.
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• W2000440143 doi "https://doi.org/10.3184/003685006783238290" @default.
• W2000440143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17338440" @default.
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