FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000441021> ?p ?o ?g. }

• W2000441021 endingPage "065102" @default.
• W2000441021 startingPage "065102" @default.
• W2000441021 abstract "A heavy-metal-free luminescent quantum dot (QD) based on doped zinc sulfide (ZnS), conjugated with a cancer-targeting ligand, folic acid (FA), is presented as a promising bio-friendly system for targeted cancer imaging. Doped QDs were prepared by a simple aqueous method at room temperature. X-ray diffraction and transmission electron microscopy studies showed the formation of monodisperse QDs of average size approximately 4 nm with cubic (sphalerite) crystal structure. Doping of the QDs with metals (Al(3+)), transition metals (Cu(+), Mn(2+)) and halides (F(-)) resulted in multi-color emission with dopant-specific color tunability ranging from blue (480 nm) to red (622 nm). Luminescent centers in doped QDs could be excited using bio-friendly visible light >400 nm by directly populating the dopant centers, leading to bright emission. The cytotoxicity of bare and FA conjugated QDs was tested in vitro using normal lung fibroblast cell line (L929), folate-receptor-positive (FR+) nasopharyngeal epidermoid carcinoma cell line (KB), and FR-negative (FR-) lung cancer cell line (A549). Both bare and FA-conjugated ZnS QDs elicited no apparent toxicity even at high concentrations of approximately 100 microM and 48 h of incubation. In contrast, CdS QDs prepared under identical conditions showed relatively high toxicity even at low concentrations of approximately 0.1 microM and 24 h of incubation. Interaction of FA-QDs with different cell lines showed highly specific attachment of QDs in the FR+ cancer cell line, leaving others unaffected. The bright and stable luminescence of the QDs could be used to image both single cancer cells and colonies of cancer cells without affecting their metabolic activity and morphology. Thus, this study presents, for the first time, the use of non-toxic, Cd-, Te-, Se-, Pb- and Hg-free luminescent QDs for targeted cancer imaging." @default.
• W2000441021 created "2016-06-24" @default.
• W2000441021 creator A5024375689 @default.
• W2000441021 creator A5028768901 @default.
• W2000441021 creator A5029755238 @default.
• W2000441021 creator A5048362281 @default.
• W2000441021 creator A5059208808 @default.
• W2000441021 creator A5069038949 @default.
• W2000441021 date "2009-01-14" @default.
• W2000441021 modified "2023-09-26" @default.
• W2000441021 title "Bio-conjugated luminescent quantum dots of doped ZnS: a cyto-friendly system for targeted cancer imaging" @default.
• W2000441021 cites W1561712812 @default.
• W2000441021 cites W1614578612 @default.
• W2000441021 cites W1799859423 @default.
• W2000441021 cites W1973590977 @default.
• W2000441021 cites W1975480898 @default.
• W2000441021 cites W1979106430 @default.
• W2000441021 cites W1983939062 @default.
• W2000441021 cites W1994065479 @default.
• W2000441021 cites W2004318321 @default.
• W2000441021 cites W2008685387 @default.
• W2000441021 cites W2011032800 @default.
• W2000441021 cites W2012128752 @default.
• W2000441021 cites W2013823475 @default.
• W2000441021 cites W2019026961 @default.
• W2000441021 cites W2020220740 @default.
• W2000441021 cites W2021597276 @default.
• W2000441021 cites W2022831883 @default.
• W2000441021 cites W2025669689 @default.
• W2000441021 cites W2032706441 @default.
• W2000441021 cites W2032735451 @default.
• W2000441021 cites W2034452678 @default.
• W2000441021 cites W2062485439 @default.
• W2000441021 cites W2063575064 @default.
• W2000441021 cites W2063672659 @default.
• W2000441021 cites W2064548903 @default.
• W2000441021 cites W2069500768 @default.
• W2000441021 cites W2079529157 @default.
• W2000441021 cites W2084357980 @default.
• W2000441021 cites W2086210408 @default.
• W2000441021 cites W2087002485 @default.
• W2000441021 cites W2087214659 @default.
• W2000441021 cites W2087518894 @default.
• W2000441021 cites W2090117150 @default.
• W2000441021 cites W2091684294 @default.
• W2000441021 cites W2112067584 @default.
• W2000441021 cites W2112101570 @default.
• W2000441021 cites W2114918609 @default.
• W2000441021 cites W2117163161 @default.
• W2000441021 cites W2118685639 @default.
• W2000441021 cites W2122426644 @default.
• W2000441021 cites W2123605247 @default.
• W2000441021 cites W2125113797 @default.
• W2000441021 cites W2133786616 @default.
• W2000441021 cites W2138376395 @default.
• W2000441021 cites W2148924929 @default.
• W2000441021 cites W2150578980 @default.
• W2000441021 cites W2157890650 @default.
• W2000441021 cites W2164845223 @default.
• W2000441021 cites W2164930985 @default.
• W2000441021 cites W2312802351 @default.
• W2000441021 cites W4244450487 @default.
• W2000441021 doi "https://doi.org/10.1088/0957-4484/20/6/065102" @default.
• W2000441021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19417370" @default.
• W2000441021 hasPublicationYear "2009" @default.
• W2000441021 type Work @default.
• W2000441021 sameAs 2000441021 @default.
• W2000441021 citedByCount "148" @default.
• W2000441021 countsByYear W20004410212012 @default.
• W2000441021 countsByYear W20004410212013 @default.
• W2000441021 countsByYear W20004410212014 @default.
• W2000441021 countsByYear W20004410212015 @default.
• W2000441021 countsByYear W20004410212016 @default.
• W2000441021 countsByYear W20004410212017 @default.
• W2000441021 countsByYear W20004410212018 @default.
• W2000441021 countsByYear W20004410212019 @default.
• W2000441021 countsByYear W20004410212020 @default.
• W2000441021 countsByYear W20004410212021 @default.
• W2000441021 countsByYear W20004410212023 @default.
• W2000441021 crossrefType "journal-article" @default.
• W2000441021 hasAuthorship W2000441021A5024375689 @default.
• W2000441021 hasAuthorship W2000441021A5028768901 @default.
• W2000441021 hasAuthorship W2000441021A5029755238 @default.
• W2000441021 hasAuthorship W2000441021A5048362281 @default.
• W2000441021 hasAuthorship W2000441021A5059208808 @default.
• W2000441021 hasAuthorship W2000441021A5069038949 @default.
• W2000441021 hasConcept C112613896 @default.
• W2000441021 hasConcept C113196181 @default.
• W2000441021 hasConcept C124657808 @default.
• W2000441021 hasConcept C148869448 @default.
• W2000441021 hasConcept C159985019 @default.
• W2000441021 hasConcept C171250308 @default.
• W2000441021 hasConcept C178790620 @default.
• W2000441021 hasConcept C185592680 @default.
• W2000441021 hasConcept C191952053 @default.
• W2000441021 hasConcept C192562407 @default.
• W2000441021 hasConcept C49040817 @default.
• W2000441021 hasConcept C521977710 @default.

• next