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- W2000441481 abstract "This is the first in a series of review articles describing the current state of research on mouse lung tumorigenesis. The system is valuable as a biological model for studying stages of tumor development and the interaction of genetic and environmental factors which dispose towards neoplasia. Additionally, these tumors are analagous to bronchiolo-alveolar cancer in man. Three pulmonary adenoma susceptibility (Pas) genes regulate susceptibility; 1 of these is the proto-oncogene, K-ras 2. Candidates for the other 2 genes include the H-2 histocompatibility locus and genes which regulate the basal proliferative rate of the cells from which these tumors arise. Tumor development is favored by a depressed immune system, immature age, and decreased levels of circulating corticosterone." @default.
- W2000441481 created "2016-06-24" @default.
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- W2000441481 date "1989-03-01" @default.
- W2000441481 modified "2023-10-17" @default.
- W2000441481 title "The genetic basis of susceptibility to lung tumors in mice" @default.
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- W2000441481 doi "https://doi.org/10.1016/0300-483x(89)90062-0" @default.
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