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- W2000443577 abstract "The synthesis of sulphated glycosaminoglycans (GAG) and hyaluronan (HA) was studied in 3 cell strains incubated at 37°C or 42°C. Cells were labelled with [ 3 H]glucosamine and [ 35 S]sulphate. No incorporation of [ 35 S]sulphate was observed at 42°C. Cellulose acetate electrophoresis of GAGs synthetized at 42°C showed only one [ 3 H]glucosamine‐labelled band completely digested with Streptomyces hyaluronidase. The quantification of [ 3 H]glucosamine‐labelled GAGs before and after hyaluronidase treatment indicated an increased rate of HA synthesis at 42°C as compared to the rate of synthesis at 37°C. These results suggest that hyperthermia stimulates HA synthesis and inhibits sulphated GAG synthesis in several cell strains which in turn may contribute to the modification of extracellular environment in inflammation." @default.
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- W2000443577 date "1993-11-08" @default.
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- W2000443577 title "Effect of hyperthermia on the extracellular matrix I. Heat enhances hyaluronan and inhibits sulphated glycosaminoglycan synthesis" @default.
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- W2000443577 doi "https://doi.org/10.1016/0014-5793(93)81695-v" @default.
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