Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000444231> ?p ?o ?g. }
- W2000444231 endingPage "1089" @default.
- W2000444231 startingPage "1080" @default.
- W2000444231 abstract "Abstract Structural microtubule‐associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc‐tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been permanently transfected with human green fluorescent protein (GFP)‐α‐tubulin were transiently transfected with myc‐tagged MAP1a fragments. Cells expressing MAP1a fragments were used to make direct observations of microtubule dynamics in living cells using fluorescence microscopy. All truncated MAP1a heavy chain fragments that contained the microtubule‐binding domain were shown to associate with microtubules. Truncated fragments containing different regions of the projection domain of MAP1a demonstrated variations in their impact on microtubule dynamic events by promoting growth or inhibition of shortening phases. In contrast to MAP1a, MAP2c bundled microtubules and resulted in a complete arrest of microtubule motility. Results from the present study suggest that MAP1a promotes slow, stable growth of microtubules. This type of growth may be important in the maintenance and restructuring of adult neurons. © 2008 Wiley‐Liss, Inc." @default.
- W2000444231 created "2016-06-24" @default.
- W2000444231 creator A5041357908 @default.
- W2000444231 creator A5090475890 @default.
- W2000444231 date "2008-10-24" @default.
- W2000444231 modified "2023-10-16" @default.
- W2000444231 title "Modulation of microtubule dynamics by the microtubule-associated protein 1a" @default.
- W2000444231 cites W1487957630 @default.
- W2000444231 cites W1827159162 @default.
- W2000444231 cites W1965404941 @default.
- W2000444231 cites W1969245469 @default.
- W2000444231 cites W1971910646 @default.
- W2000444231 cites W1983197254 @default.
- W2000444231 cites W1986394856 @default.
- W2000444231 cites W1990208059 @default.
- W2000444231 cites W1990596544 @default.
- W2000444231 cites W1993294655 @default.
- W2000444231 cites W1994945404 @default.
- W2000444231 cites W2000962193 @default.
- W2000444231 cites W2002699042 @default.
- W2000444231 cites W2005759705 @default.
- W2000444231 cites W2011783950 @default.
- W2000444231 cites W2012717648 @default.
- W2000444231 cites W2015171213 @default.
- W2000444231 cites W2019128246 @default.
- W2000444231 cites W2021172919 @default.
- W2000444231 cites W2026971413 @default.
- W2000444231 cites W2028084729 @default.
- W2000444231 cites W2039270622 @default.
- W2000444231 cites W2043278329 @default.
- W2000444231 cites W2045306609 @default.
- W2000444231 cites W2046624741 @default.
- W2000444231 cites W2047841570 @default.
- W2000444231 cites W2051861508 @default.
- W2000444231 cites W2052065403 @default.
- W2000444231 cites W2054428754 @default.
- W2000444231 cites W2066810065 @default.
- W2000444231 cites W2071817332 @default.
- W2000444231 cites W2075876646 @default.
- W2000444231 cites W2082490153 @default.
- W2000444231 cites W2086935111 @default.
- W2000444231 cites W2089377198 @default.
- W2000444231 cites W2091616303 @default.
- W2000444231 cites W2101108802 @default.
- W2000444231 cites W2102093857 @default.
- W2000444231 cites W2115886897 @default.
- W2000444231 cites W2123513862 @default.
- W2000444231 cites W2138801576 @default.
- W2000444231 cites W2148327308 @default.
- W2000444231 cites W2159159780 @default.
- W2000444231 cites W2160862460 @default.
- W2000444231 cites W2170191832 @default.
- W2000444231 cites W2186134624 @default.
- W2000444231 cites W2345662142 @default.
- W2000444231 doi "https://doi.org/10.1002/jnr.21920" @default.
- W2000444231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18951470" @default.
- W2000444231 hasPublicationYear "2008" @default.
- W2000444231 type Work @default.
- W2000444231 sameAs 2000444231 @default.
- W2000444231 citedByCount "12" @default.
- W2000444231 countsByYear W20004442312012 @default.
- W2000444231 countsByYear W20004442312013 @default.
- W2000444231 countsByYear W20004442312014 @default.
- W2000444231 countsByYear W20004442312015 @default.
- W2000444231 countsByYear W20004442312016 @default.
- W2000444231 crossrefType "journal-article" @default.
- W2000444231 hasAuthorship W2000444231A5041357908 @default.
- W2000444231 hasAuthorship W2000444231A5090475890 @default.
- W2000444231 hasConcept C10447061 @default.
- W2000444231 hasConcept C121332964 @default.
- W2000444231 hasConcept C12554922 @default.
- W2000444231 hasConcept C1491633281 @default.
- W2000444231 hasConcept C169274487 @default.
- W2000444231 hasConcept C20418707 @default.
- W2000444231 hasConcept C29537977 @default.
- W2000444231 hasConcept C55493867 @default.
- W2000444231 hasConcept C58207958 @default.
- W2000444231 hasConcept C61081601 @default.
- W2000444231 hasConcept C62520636 @default.
- W2000444231 hasConcept C84425145 @default.
- W2000444231 hasConcept C86803240 @default.
- W2000444231 hasConcept C91881484 @default.
- W2000444231 hasConcept C94921385 @default.
- W2000444231 hasConcept C95444343 @default.
- W2000444231 hasConceptScore W2000444231C10447061 @default.
- W2000444231 hasConceptScore W2000444231C121332964 @default.
- W2000444231 hasConceptScore W2000444231C12554922 @default.
- W2000444231 hasConceptScore W2000444231C1491633281 @default.
- W2000444231 hasConceptScore W2000444231C169274487 @default.
- W2000444231 hasConceptScore W2000444231C20418707 @default.
- W2000444231 hasConceptScore W2000444231C29537977 @default.
- W2000444231 hasConceptScore W2000444231C55493867 @default.
- W2000444231 hasConceptScore W2000444231C58207958 @default.
- W2000444231 hasConceptScore W2000444231C61081601 @default.
- W2000444231 hasConceptScore W2000444231C62520636 @default.
- W2000444231 hasConceptScore W2000444231C84425145 @default.
- W2000444231 hasConceptScore W2000444231C86803240 @default.
- W2000444231 hasConceptScore W2000444231C91881484 @default.