FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000444385> ?p ?o ?g. }

• W2000444385 endingPage "518" @default.
• W2000444385 startingPage "513" @default.
• W2000444385 abstract "Extracellular adenosine triphosphate (ATP) is sequentially dephosphorylated by two ectoenzymes: CD39/nucleotidase triphosphate dephosphorylase (ENTPD) and CD73/5′-ectonucleotidase (5′-NT). Adenosine, its notable metabolite, may elicit potent anti-inflammatory responses. We examined whether the CD39-adenosinergic axis may exist in gingival fibroblasts and have an effect on the expression of matrix metalloproteinase (MMP)-1, the excess production of which leads to pathological matrix degradation. We showed that transcripts of CD39, CD73, and adenosine receptors A1, A2a, and A2b, but not A3, were expressed by human gingival fibroblasts by RT-PCR. We also identified the expression of CD39 in fibroblastic cells in rat gingiva by immunohistochemistry. ATP inhibited the expression of MMP-1 triggered by interleukin-1 at gene and protein levels. However, ATP-γS, a stable ATP analog, did not. The ATP-mediated MMP-1 inhibition was restored in the presence of POM-1, a specific ENTPD inhibitor, suggesting that CD39/ENTPD was involved in the MMP-1 inhibition. ATP metabolites including adenosine 5′-diphosphate (ADP), adenosine 5′-monophosphate (AMP), and adenosine inhibited MMP-1 expression, but ADP-βS, a stable ADP, did not, suggesting that adenosine converted from ATP by the action of CD39/ENTPD and CD73/5′-NT may contribute to MMP-1 inhibition. Adenosine-mediated MMP-1 inhibition was restored in the presence of H89, a protein kinase A (PKA) inhibitor. Conversely, forskolin, an enhancer of intracellular cAMP, mimicked the effect of adenosine, suggesting that the cAMP/PKA signaling pathway is involved in adenosine-mediated MMP-1 inhibition. The present findings suggest the existence of an endogenous anti-tissue destructive mechanism in gingival tissue via the CD39-adenosinergic axis." @default.
• W2000444385 created "2016-06-24" @default.
• W2000444385 creator A5048820344 @default.
• W2000444385 creator A5057011798 @default.
• W2000444385 creator A5063997319 @default.
• W2000444385 creator A5073870257 @default.
• W2000444385 creator A5076385445 @default.
• W2000444385 date "2013-11-01" @default.
• W2000444385 modified "2023-09-26" @default.
• W2000444385 title "Extracellular ATP inhibits IL-1-induced MMP-1 expression through the action of CD39/nucleotidase triphosphate dephosphorylase-1 on human gingival fibroblasts" @default.
• W2000444385 cites W1554947160 @default.
• W2000444385 cites W1965130745 @default.
• W2000444385 cites W1980763771 @default.
• W2000444385 cites W1981668097 @default.
• W2000444385 cites W1981886106 @default.
• W2000444385 cites W1981919734 @default.
• W2000444385 cites W1985407729 @default.
• W2000444385 cites W2002357052 @default.
• W2000444385 cites W2018150386 @default.
• W2000444385 cites W2025059389 @default.
• W2000444385 cites W2025571426 @default.
• W2000444385 cites W2026813843 @default.
• W2000444385 cites W2027226283 @default.
• W2000444385 cites W2028067028 @default.
• W2000444385 cites W2032166065 @default.
• W2000444385 cites W2034442219 @default.
• W2000444385 cites W2037178734 @default.
• W2000444385 cites W2037816904 @default.
• W2000444385 cites W2057693726 @default.
• W2000444385 cites W2060927696 @default.
• W2000444385 cites W2070616314 @default.
• W2000444385 cites W2075239726 @default.
• W2000444385 cites W2078544167 @default.
• W2000444385 cites W2082417162 @default.
• W2000444385 cites W2085403057 @default.
• W2000444385 cites W2085498155 @default.
• W2000444385 cites W2092509331 @default.
• W2000444385 cites W2093113166 @default.
• W2000444385 cites W2095988220 @default.
• W2000444385 cites W2108805208 @default.
• W2000444385 cites W2137141750 @default.
• W2000444385 cites W2163178183 @default.
• W2000444385 cites W2292535579 @default.
• W2000444385 doi "https://doi.org/10.1016/j.intimp.2013.07.014" @default.
• W2000444385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23941770" @default.
• W2000444385 hasPublicationYear "2013" @default.
• W2000444385 type Work @default.
• W2000444385 sameAs 2000444385 @default.
• W2000444385 citedByCount "5" @default.
• W2000444385 countsByYear W20004443852015 @default.
• W2000444385 countsByYear W20004443852018 @default.
• W2000444385 countsByYear W20004443852019 @default.
• W2000444385 countsByYear W20004443852022 @default.
• W2000444385 countsByYear W20004443852023 @default.
• W2000444385 crossrefType "journal-article" @default.
• W2000444385 hasAuthorship W2000444385A5048820344 @default.
• W2000444385 hasAuthorship W2000444385A5057011798 @default.
• W2000444385 hasAuthorship W2000444385A5063997319 @default.
• W2000444385 hasAuthorship W2000444385A5073870257 @default.
• W2000444385 hasAuthorship W2000444385A5076385445 @default.
• W2000444385 hasConcept C153911025 @default.
• W2000444385 hasConcept C170493617 @default.
• W2000444385 hasConcept C172590197 @default.
• W2000444385 hasConcept C185592680 @default.
• W2000444385 hasConcept C18880352 @default.
• W2000444385 hasConcept C2776991684 @default.
• W2000444385 hasConcept C2777913276 @default.
• W2000444385 hasConcept C2778938600 @default.
• W2000444385 hasConcept C2779508331 @default.
• W2000444385 hasConcept C2779564974 @default.
• W2000444385 hasConcept C2779876172 @default.
• W2000444385 hasConcept C2780876210 @default.
• W2000444385 hasConcept C28406088 @default.
• W2000444385 hasConcept C34628245 @default.
• W2000444385 hasConcept C55493867 @default.
• W2000444385 hasConcept C67907053 @default.
• W2000444385 hasConcept C86803240 @default.
• W2000444385 hasConceptScore W2000444385C153911025 @default.
• W2000444385 hasConceptScore W2000444385C170493617 @default.
• W2000444385 hasConceptScore W2000444385C172590197 @default.
• W2000444385 hasConceptScore W2000444385C185592680 @default.
• W2000444385 hasConceptScore W2000444385C18880352 @default.
• W2000444385 hasConceptScore W2000444385C2776991684 @default.
• W2000444385 hasConceptScore W2000444385C2777913276 @default.
• W2000444385 hasConceptScore W2000444385C2778938600 @default.
• W2000444385 hasConceptScore W2000444385C2779508331 @default.
• W2000444385 hasConceptScore W2000444385C2779564974 @default.
• W2000444385 hasConceptScore W2000444385C2779876172 @default.
• W2000444385 hasConceptScore W2000444385C2780876210 @default.
• W2000444385 hasConceptScore W2000444385C28406088 @default.
• W2000444385 hasConceptScore W2000444385C34628245 @default.
• W2000444385 hasConceptScore W2000444385C55493867 @default.
• W2000444385 hasConceptScore W2000444385C67907053 @default.
• W2000444385 hasConceptScore W2000444385C86803240 @default.
• W2000444385 hasFunder F4320334764 @default.
• W2000444385 hasIssue "3" @default.
• W2000444385 hasLocation W20004443851 @default.
• W2000444385 hasLocation W20004443852 @default.

• next