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• W2000445323 abstract "Galectin‐8 is a tandem‐repeat‐type β‐galactoside‐specific animal lectin possessing N ‐terminal and C ‐terminal carbohydrate recognition domains ( N ‐ CRD and C ‐ CRD , respectively), with a difference in carbohydrate‐binding specificity, involved in cell–matrix interaction, malignant transformation, and cell adhesion. N ‐ CRD shows strong affinity for α2–3‐sialylated oligosaccharides, a feature unique to galectin‐8. C ‐ CRD usually shows lower affinity for oligosaccharides but higher affinity for N ‐glycan‐type branched oligosaccharides than does N ‐ CRD . There have been many structural studies on galectins with a single carbohydrate recognition domain ( CRD ), but no X ‐ray structure of a galectin containing both CRD s has been reported. Here, the X ‐ray structure of a protease‐resistant mutant form of human galectin‐8 possessing both CRD s and the novel pseudodimer structure of galectin‐8 N ‐ CRD in complexes with α2–3‐sialylated oligosaccharide ligands were determined. The results revealed a difference in specificity between N ‐ CRD and C ‐ CRD , and provided new insights into the association of CRD s and/or molecules of galectin‐8. Database The atomic coordinates and structure factors of G 8 N ull– L ac, G 8 N ull–2 L ac, G 8 N ull– S ia L ac– L ac, G 8 N ‐free and G 8 N – S ia L ac NA c have been deposited in the P rotein D ata B ank under the accession codes 4FQZ , 3VKL , 3VKM , 3VKN , and 3VKO , respectively. Structured digital abstract G8 and G8 bind by x‐ray crystallography ( View interaction )" @default.
• W2000445323 created "2016-06-24" @default.
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• W2000445323 date "2012-09-11" @default.
• W2000445323 modified "2023-10-17" @default.
• W2000445323 title "<scp>X</scp>‐ray structure of a protease‐resistant mutant form of human galectin‐8 with two carbohydrate recognition domains" @default.
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• W2000445323 doi "https://doi.org/10.1111/j.1742-4658.2012.08753.x" @default.
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