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• W2000445360 abstract "The glial cell response to anti-galactocerebroside (GC) induced demyelination of the cat optic nerve was studied using electron microscopy and immunocytochemistry. Oligodendrocytes, which are a primary target for anti-GC, were depleted in the early lesions but astrocytes survived and showed reactive changes. Astrocytic processes exhibited dual staining for both GC and glialfibrillary acidic protein, a feature not seen in astrocytes outside the lesion or in normal optic nerve. These reactive astrocytes did not stain for anti-myelin basic protein, nor did they contain myelin debris, making it unlikely that the GC immunoreactivity was due to phagocytosis of myelin. Rather, it is postulated that the presence of GC in these cells represents a process of dedifferentiation to a more primitive state in which both astrocytic and oligodendrocytic determinants are synthesised, and that these reactive glial cells may be precursors of a new population of remyelinating oligodendrocytes." @default.
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• W2000445360 date "1987-05-01" @default.
• W2000445360 modified "2023-09-28" @default.
• W2000445360 title "Reactive glial cells in CNS demyelination contain both GC and GFAP" @default.
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• W2000445360 doi "https://doi.org/10.1016/0006-8993(87)91088-2" @default.
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