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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000446241> ?p ?o ?g. }

• W2000446241 endingPage "173" @default.
• W2000446241 startingPage "165" @default.
• W2000446241 abstract "The regulation of the growth of the pancreatic β-cell is poorly understood. There are previous indications of a role of GH in the growth and insulin production of the pancreatic islets. In the present study we present evidence for a direct long-term effect of GH on proliferation and insulin biosynthesis of pancreatic β-cells in monolayer culture. In culture medium RPMI 1640 supplemented with 2% normal human serum islets or dissociated islet cells from newborn rats maintained their insulin-producing capacity. When supplemented with 1–1000 ng/ml pituitary or recombinant human GH the islet cells attached, spread out, and proliferated into monolayers mainly consisting of insulin-containing cells. The number of β-cells in S-phase was increased from 0.9–6.5% as determined by immunochemical staining of bromodeoxyuridine incorporated into insulinpositive cells. The increase in cell number was accompanied with a continuous increase in insulin release to the culture medium reaching a 10- 20-fold increase after 2–3 months with a half-maximal effect at about 10 ng/ml human GH. The biosynthesis of (pro)insulin was markedly increased with a normal rate of conversion of proinsulin to insulin. It is concluded that GH is a potent growth factor for the differentiated pancreatic β-cell" @default.
• W2000446241 created "2016-06-24" @default.
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• W2000446241 date "1989-01-01" @default.
• W2000446241 modified "2023-10-15" @default.
• W2000446241 title "Growth Hormone is a Growth Factor for the Differentiated Pancreatic β-Cell" @default.
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• W2000446241 doi "https://doi.org/10.1210/mend-3-1-165" @default.
• W2000446241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2644530" @default.
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