FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2000447621> ?p ?o ?g. }

• W2000447621 endingPage "549" @default.
• W2000447621 startingPage "541" @default.
• W2000447621 abstract "Astrocytes are involved, as are microglia/macrophages [Martyet al. (1991)Neuroscience45, 529–539], in the formation of a glial scar after CNS lesions. This study was undertaken to follow the time-course of changes in the morphology and distribution of astrocytes that takes place during the formation of a glial scar after kainic acid injection in the rat thalamus. The astrocytes were identified using an antibody raised against glial fibrillary acidic protein (GFAP) and the progression of their reaction to the lesion was followed from 24 h to one year after the kainate injection. Three periods could be distinguished during the evolution of the astrocytic response in the neurondepleted area. There was an initial appearance of a large number of GFAP + cells. These cells displayed profound morphological differences from the normal. They were enlarged, round and devoid of processes. These GFAP + astrocytes disappeared four days after the lesion. This increase of the GFAP + cells in the neuron-depleted area may be due to cytoskeletal changes and thus an increased exposure of antigenic sites. In a second period between four and 14 days, the only GFAP + elements present in the neuron-depleted area were long and straight processes. These processes entered the lesioned area from the periphery and seemed to follow axon bundles. Additionally, during the first weeks, the number of reactive astrocytes increased in a small band just around the area of neuronal loss. The third period began after two weeks. The lesioned area became gradually occupied by GFAP + astrocytes. These astrocytes were of two types. The first type had the morphology of reactive astrocytes; they were located first at the periphery then progressively in more central zones, and seemed associated with blood vessels, suggesting an inward migration of cells from surrounding areas. The second type was small and appeared simultaneously throughout the area of neuronal loss, suggesting GFAP expression in previously silent astrocytes. These cells could be derived from precursors existing in the adult CNS. The astrocytes were the predominant element in the neuron-depleted area after one month. They became further hypertrophied and formed a dense network over the following months. In summary, reactive astrocytes increase in number during the first month in an area depleted of neurons by an excitotoxin. During this first period microglia/macrophages are, however, the predominant cell population and it is only after the first month that astrocytes form the classical glial scar." @default.
• W2000447621 created "2016-06-24" @default.
• W2000447621 creator A5007391820 @default.
• W2000447621 creator A5064759494 @default.
• W2000447621 creator A5084576487 @default.
• W2000447621 date "1991-01-01" @default.
• W2000447621 modified "2023-09-25" @default.
• W2000447621 title "Glial changes following an excitotoxic lesion in the CNS—II. Astrocytes" @default.
• W2000447621 cites W1520307593 @default.
• W2000447621 cites W1592789336 @default.
• W2000447621 cites W1970159071 @default.
• W2000447621 cites W1980168868 @default.
• W2000447621 cites W1981435269 @default.
• W2000447621 cites W1987833892 @default.
• W2000447621 cites W1993129113 @default.
• W2000447621 cites W1994208942 @default.
• W2000447621 cites W2001742897 @default.
• W2000447621 cites W2004688814 @default.
• W2000447621 cites W2006504264 @default.
• W2000447621 cites W2007214804 @default.
• W2000447621 cites W2007884285 @default.
• W2000447621 cites W2014682180 @default.
• W2000447621 cites W2019956654 @default.
• W2000447621 cites W2023402827 @default.
• W2000447621 cites W2030770860 @default.
• W2000447621 cites W2035271343 @default.
• W2000447621 cites W2040913237 @default.
• W2000447621 cites W2056741720 @default.
• W2000447621 cites W2057648028 @default.
• W2000447621 cites W2058787448 @default.
• W2000447621 cites W2068029268 @default.
• W2000447621 cites W2070709069 @default.
• W2000447621 cites W2071369096 @default.
• W2000447621 cites W2079027936 @default.
• W2000447621 cites W2083837529 @default.
• W2000447621 cites W2084327649 @default.
• W2000447621 cites W2085310064 @default.
• W2000447621 cites W2087410244 @default.
• W2000447621 cites W2087587497 @default.
• W2000447621 cites W2089898619 @default.
• W2000447621 cites W2090971379 @default.
• W2000447621 cites W3004013953 @default.
• W2000447621 cites W4241916785 @default.
• W2000447621 cites W4366658026 @default.
• W2000447621 doi "https://doi.org/10.1016/0306-4522(91)90269-t" @default.
• W2000447621 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1775232" @default.
• W2000447621 hasPublicationYear "1991" @default.
• W2000447621 type Work @default.
• W2000447621 sameAs 2000447621 @default.
• W2000447621 citedByCount "141" @default.
• W2000447621 countsByYear W20004476212012 @default.
• W2000447621 countsByYear W20004476212013 @default.
• W2000447621 countsByYear W20004476212014 @default.
• W2000447621 countsByYear W20004476212018 @default.
• W2000447621 countsByYear W20004476212019 @default.
• W2000447621 countsByYear W20004476212020 @default.
• W2000447621 countsByYear W20004476212021 @default.
• W2000447621 countsByYear W20004476212022 @default.
• W2000447621 crossrefType "journal-article" @default.
• W2000447621 hasAuthorship W2000447621A5007391820 @default.
• W2000447621 hasAuthorship W2000447621A5064759494 @default.
• W2000447621 hasAuthorship W2000447621A5084576487 @default.
• W2000447621 hasConcept C142724271 @default.
• W2000447621 hasConcept C159431405 @default.
• W2000447621 hasConcept C160268369 @default.
• W2000447621 hasConcept C169760540 @default.
• W2000447621 hasConcept C170493617 @default.
• W2000447621 hasConcept C189184402 @default.
• W2000447621 hasConcept C203014093 @default.
• W2000447621 hasConcept C204232928 @default.
• W2000447621 hasConcept C2776108384 @default.
• W2000447621 hasConcept C2776914184 @default.
• W2000447621 hasConcept C2777542381 @default.
• W2000447621 hasConcept C2777594495 @default.
• W2000447621 hasConcept C2778794669 @default.
• W2000447621 hasConcept C2779530196 @default.
• W2000447621 hasConcept C2779830541 @default.
• W2000447621 hasConcept C2780495277 @default.
• W2000447621 hasConcept C2780884517 @default.
• W2000447621 hasConcept C2781156865 @default.
• W2000447621 hasConcept C529278444 @default.
• W2000447621 hasConcept C55493867 @default.
• W2000447621 hasConcept C61174792 @default.
• W2000447621 hasConcept C71924100 @default.
• W2000447621 hasConcept C86803240 @default.
• W2000447621 hasConceptScore W2000447621C142724271 @default.
• W2000447621 hasConceptScore W2000447621C159431405 @default.
• W2000447621 hasConceptScore W2000447621C160268369 @default.
• W2000447621 hasConceptScore W2000447621C169760540 @default.
• W2000447621 hasConceptScore W2000447621C170493617 @default.
• W2000447621 hasConceptScore W2000447621C189184402 @default.
• W2000447621 hasConceptScore W2000447621C203014093 @default.
• W2000447621 hasConceptScore W2000447621C204232928 @default.
• W2000447621 hasConceptScore W2000447621C2776108384 @default.
• W2000447621 hasConceptScore W2000447621C2776914184 @default.
• W2000447621 hasConceptScore W2000447621C2777542381 @default.
• W2000447621 hasConceptScore W2000447621C2777594495 @default.
• W2000447621 hasConceptScore W2000447621C2778794669 @default.

• next