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• W2000448219 endingPage "1113" @default.
• W2000448219 startingPage "1106" @default.
• W2000448219 abstract "Many hypothalamic neuropeptides are involved in the regulation of energy homeostasis and feeding behavior. We have investigated whether and to what extent neuropeptide Y (NPY), agouti-related protein (AGRP), melanin-concentrating hormone (MCH), and prepro-orexin (prepro-OX) as well as pro-opiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript (CART) mRNA levels are affected in rat hypothalamus. An experimental model of long-term fasting rat characterized by three metabolic phases from changes in lipid and protein utilization was used. Except for prepro-OX and compared to fed group, starvation induced an increase in the orexigenic gene expressions that was much more marked in phase 3 (by 2.5-, 8.1-, and 13.5-fold for MCH, AGRP, and NPY, respectively) than in phase 2 (by about 1.5-2.2-fold as an average) of fasting. AGRP and NPY mRNA levels were inversely related to body fat content. Anorexigenic gene expression was only slightly affected at both fasting stages. We conclude that the regulation of NPY and AGRP gene expression is primarily involved during late fasting and could mediate the concomitant enhanced drive for refeeding." @default.
• W2000448219 created "2016-06-24" @default.
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• W2000448219 creator A5080327662 @default.
• W2000448219 date "2003-04-01" @default.
• W2000448219 modified "2023-09-25" @default.
• W2000448219 title "Hypothalamic gene expression in long-term fasted rats: relationship with body fat" @default.
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• W2000448219 doi "https://doi.org/10.1016/s0006-291x(03)00481-9" @default.
• W2000448219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12684050" @default.
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